1411413-50-7Relevant articles and documents
Structure and thermodynamical properties of metformin salicylate
Perez-Fernandez,Fresno,Goya,Elguero,Menendez-Taboada,Garcia-Granda,Marco
, p. 1780 - 1785 (2013)
The behavior under thermal conditions of the cocrystal formed by metformin and salicylic acid was studied by DSC, crystallography (single-crystal), and powder diffraction (WAXS). Metformin salicylate crystallizes in space group P21/c, with the salicylate anion showing a planar structure, stabilized by strong intramolecular hydrogen bonds. The more flexible metformin cations link through the oxygen atoms of salicylate, forming a dense hydrogen-bonding network. The compound exists initially as a salt, metformin salicylate, but after melting and cooling, it is transformed into a glass form that crystallizes and melts again, showing different behaviors depending on the heating rate.
