141177-22-2

Basic information

• Product Name: 1-Pentanol, 5-(phenylmethoxy)-, 4-methylbenzenesulfonate
• CAS NO: 141177-22-2
• Molecular Formula: C19H24O4S
• Molecular Weight: 348.463
• Mol File: 141177-22-2.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 1-Pentanol, 5-(phenylmethoxy)-, 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pentanol, 5-(phenylmethoxy)-, 4-methylbenzenesulfonate(141177-22-2)
• EPA Substance Registry System: 1-Pentanol, 5-(phenylmethoxy)-, 4-methylbenzenesulfonate(141177-22-2)

Safety Data

• Hazardous Substances Data: 141177-22-2(Hazardous Substances Data)

Upstream product

• 4541-15-5 5-(benzyloxy)-1-pentanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 100-39-0 benzyl bromide 
• 111-29-5 1 ,5-pentanediol 

Downstream Products

• 1262964-28-2 (2-((5-fluoropentyl)oxy)ethyl)benzene 
• 592-80-3 5-fluoro-1-pentanol 
• 2653-86-3 (pent-4-en-1-yloxy)benzene 
• 141177-17-5 8-azi-13-O-benzyl-6,7,8,9,10,11,12-heptadeoxy-1,2:3,4-di-O-isopropylidene-α-D-galacto-tridecopyranose 
• 141177-16-4 13-O-benzyl-6,7,9,10,11,12-hexadeoxy-1,2:3,4-di-O-isopropylidene-α-D-galacto-tridecopyranos-8-ulose 
• 141177-15-3 13-O-benzyl-6,7,9,10,11,12-hexadeoxy-1,2:3,4-di-O-isopropylidene-DL-glycero-α-D-galacto-tridecopyranose 
• 284666-59-7 tetra-O-benzyl danoxamine 
• 284666-57-5 28-(tert-butoxycarbonyl)-1,6,17,29-tetrakis(benzyloxy)-7,10,18,21-tetraoxo-6,11,17,22,28-pentaazaoctacosane 
• 284666-64-4 1,6,17,29-tetrakis(benzyloxy)-7,10,18,21-tetraoxo-6,11,17,22,28-pentaazaoctacosane 
• 284666-55-3 5,16,21-tris(benzyloxy)-4,12,15-trioxo-5,11,16-triazahenicosanoic acid 
• 284666-53-1 17-(tert-butoxycarbonyl)-1,6,17-tris(benzyloxy)-7,10-dioxo-6,11,17-triazaheptadecane 
• 284666-62-2 1,6,17-tris(benzyloxy)-7,10-dioxo-6,11,17-triazaheptadecane 
• 284666-50-8 N-(benzyloxy)-N-(5-benzyloxypentyl)succinamic acid 
• 284666-44-0 N-(5-benzyloxypentyl)-O-benzylhydroxylamine 

Relevant articles and documents

Systematic Investigation of the Permeability of Androgen Receptor PROTACs

Bifunctional molecules known as PROTACs simultaneously bind an E3 ligase and a protein of interest to direct ubiquitination and clearance of that protein, and they have emerged in the past decade as an exciting new paradigm in drug discovery. In order to investigate the permeability and properties of these large molecules, we synthesized two panels of PROTAC molecules, constructed from a range of protein-target ligands, linkers, and E3 ligase ligands. The androgen receptor, which is a well-studied protein in the PROTAC field was used as a model system. The physicochemical properties and permeability of PROTACs are discussed.

SMALL MOLECULES

Compounds having the general structure A - L - B are presented wherein A and B are independently an E3 ubiquitin ligase protein binding ligand compound of formula 1A or 1 B. Pharmaceutical compositions comprising these compounds and methods of use are also presented.

Catalytic nucleophilic fluorination by an imidazolium ionic liquid possessing trialkylphosphine oxide functionality

Abstract The synthesis of a new alkylmethylimidazolium ionic liquid wherein the alkyl group is functionalized with dihexylphosphine oxide moiety at the terminal position has been achieved in four steps from 1-methylimidazole. This hybrid ionic liquid effectively catalyzed the nucleophilic fluorination of primary alkyl mesylates under mild conditions using CsF as the fluoride source with a faster rate compared to butylmethylimidazolium mesylate. The hybrid catalyst was recycled 5 times without compromising the yield and purity of the product. The nucleophilic fluorination has been used for the synthesis of diethyl 2-(5-fluoropentyl)-2-methyl malonate, a precursor of 18F isotopomer of an apoptosis imaging agent and the protected form of O-(2'-fluoroethyl)-l-tyrosine, a 18F isotopomer of a tumor imaging agent.