141184-49-8Relevant articles and documents
Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
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, (2008/06/13)
There are disclosed compounds of the formula STR1 wherein R is STR2 R1 is hydrogen, lower alkyl or STR3 a is 1-3; b is 1-3; c is 0-2; X, Y and Z are each, independently, a bond, O, S. or NH, with the proviso that if one of X or Y is O, S or NH, the other must be a bond; R2 is amino, loweralkylamino, arylamino, loweralkoxy or aryloxy; R3 is hydrogen, halo, hydroxy, lower alkoxy, aryloxy, loweralkanoyloxy, amino, lower alkylamino, arylamino or loweralkanoylamino; R4 and R5 are each, independently hydrogen or lower alkyl; m is 0-4; n is 1-4; and o is 1-4; and, which by virtue of their ability to selectively inhibit an isoenzyme of 3':5'-cyclic AMP phosphodiesterase located in pulmonary smooth muscle tissue and inflammatory cells, are bronchodilatory and antinflammatory and so are useful in the treatment of acute and chronic bronchial asthma and associated pathologies.