1411983-49-7

Basic information

• Product Name: 3-bromo-N′-((6-ethyl-4-oxo-4H-chromen-3-yl)methylene)benzohydrazide
• Synonyms: 3-bromo-N′-((6-ethyl-4-oxo-4H-chromen-3-yl)methylene)benzohydrazide
• CAS NO: 1411983-49-7
• Molecular Weight: 399.244
• Mol File: 1411983-49-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-bromo-N′-((6-ethyl-4-oxo-4H-chromen-3-yl)methylene)benzohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-N′-((6-ethyl-4-oxo-4H-chromen-3-yl)methylene)benzohydrazide(1411983-49-7)
• EPA Substance Registry System: 3-bromo-N′-((6-ethyl-4-oxo-4H-chromen-3-yl)methylene)benzohydrazide(1411983-49-7)

Safety Data

• Hazardous Substances Data: 1411983-49-7(Hazardous Substances Data)

Upstream product

• 42059-78-9 6-ethyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde 
• 39115-96-3 3-bromo-benzoic acid hydrazide 
• 24539-92-2 3-ethyl-6-hydroxyacetophenone 
• 3245-23-6 p-ethylphenyl acetate 
• 123-07-9 4-Ethylphenol 

Relevant articles and documents

Design and syntheses of novel N′-((4-oxo-4H-chromen-3-yl)methylene) benzohydrazide as inhibitors of cyanobacterial fructose-1,6-/sedoheptulose-1,7- bisphosphatase

Cyanobacterial fructose-1,6-/sedoheptulose-1,7-bisphoshatase (Cy-FBP/SBPase) is an important target enzyme for finding inhibitors to solve harmful algal bloom (HAB). In this study, as potential inhibitors of Cy-FBP/SBPase, a series of novel chromone-connecting benzohydrazone compounds (Novel N′-((4-oxo-4H-chromen-3-yl)methylene)benzohydrazide) were designed and synthesized. Their inhibitory activities against Cy-FBP/SBPase were further examined in vitro. Some of these compounds, such as f6-f8, f11, f12 and f16, exhibit higher inhibitory activities (IC50 = 11.2-16.1 μM), especially, the compound f7 was identified as the most potent inhibitor with IC50 value of 11.2 μM. The probable binding-mode of compound f7 was further analyzed carefully by molecular docking methods. These results indicate that compound f7 could be used as a lead compound for further optimization and might have potential to be developed as a new algicide.