14120-13-9

Basic information

• Product Name: 4-iodo-5-nitro-1,2-dimethoxybenzene
• Synonyms: 4-iodo-5-nitro-1,2-dimethoxybenzene
• CAS NO: 14120-13-9
• Molecular Weight: 309.06
• Mol File: 14120-13-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-iodo-5-nitro-1,2-dimethoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-iodo-5-nitro-1,2-dimethoxybenzene(14120-13-9)
• EPA Substance Registry System: 4-iodo-5-nitro-1,2-dimethoxybenzene(14120-13-9)

Safety Data

• Hazardous Substances Data: 14120-13-9(Hazardous Substances Data)

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 4998-07-6 4,5-dimethoxy-2-nitro-benzoic acid 
• 61203-53-0 2-iodo-4,5-dimethoxybenzaldehyde 
• 110190-08-4 1,2-diiodo-4,5-dimethoxybenzene 

Downstream Products

• 1301219-37-3 C₁₄H₁₅NO₆ 
• 1301219-62-4 C₁₃H₁₅NO₆ 
• 1372854-38-0 (R/S)-1-(4,5-dimethoxy-2-nitrophenyl)-2,2-dimethyl-1-propanol 

Relevant articles and documents

Inexpensive NaX (X = I, Br, Cl) as a halogen donor in the practical Ag/Cu-mediated decarboxylative halogenation of aryl carboxylic acids under aerobic conditions

Versatile and practical Ag/Cu-mediated decarboxylative halogenation between readily available aryl carboxylic acids and abundant NaX (X = I, Br, Cl) has been achieved under aerobic conditions in moderate to good yields. The halodecarboxylation is shown to be an effective strategy for S-containing heteroaromatic carboxylic acid and benzoic acids with nitro, chloro and methoxyl substituents at the ortho position. A gram-scale reaction and a three-step procedure to synthesize iniparib have been performed to evaluate the practicality of this protocol. A preliminary mechanistic investigation indicates that Cu plays a vital role and a radical pathway is involved in the transformation.

Decarboxylative Halogenation and Cyanation of Electron-Deficient Aryl Carboxylic Acids via Cu Mediator as Well as Electron-Rich Ones through Pd Catalyst under Aerobic Conditions

Simple strategies for decarboxylative functionalizations of electron-deficient benzoic acids via using Cu(I) as promoter and electron-rich ones by employing Pd(II) as catalyst under aerobic conditions have been established, which lead to smooth synthesis of aryl halides (-I, Br, and Cl) through the decarboxylative functionalization of benzoic acids with readily available halogen sources CuX (X = I, Br, Cl), and easy preparation of benzonitriles from decarboxylative cyanation of aryl carboxylic acids with nontoxic and low-cost K4Fe(CN)6 under an oxygen atmosphere for the first time.

Stereochemistry of benzylic carbon substitution coupled with ring modification of 2-nitrobenzyl groups as key determinants for fast-cleaving reversible terminators

A complete set of 2-nitrobenzyl-modified reversible terminators have been developed, which upon exposure to UV light generate natural hydroxymethyl nucleotides (see scheme). The combination of a stereospecific (S)-tert-butyl group (R) at the benzylic carb