141206-98-6

Basic information

• Product Name: [5-((2E,4E)-(R)-6-{2-[(E)-(2R,6S)-2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-8,8-diethoxy-oct-4-enyl]-[1,3]dithian-2-yl}-6-methoxy-2-methyl-hexa-2,4-dienyl)-2-chloro-3-methoxy-phenyl]-methyl-carbamic acid methyl ester
• Synonyms: [5-((2E,4E)-(R)-6-{2-[(E)-(2R,6S)-2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-8,8-diethoxy-oct-4-enyl]-[1,3]dithian-2-yl}-6-methoxy-2-methyl-hexa-2,4-dienyl)-2-chloro-3-methoxy-phenyl]-methyl-carbamic acid methyl ester
• CAS NO: 141206-98-6
• Molecular Weight: 930.899
• Mol File: 141206-98-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [5-((2E,4E)-(R)-6-{2-[(E)-(2R,6S)-2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-8,8-diethoxy-oct-4-enyl]-[1,3]dithian-2-yl}-6-methoxy-2-methyl-hexa-2,4-dienyl)-2-chloro-3-methoxy-phenyl]-methyl-carbamic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [5-((2E,4E)-(R)-6-{2-[(E)-(2R,6S)-2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-8,8-diethoxy-oct-4-enyl]-[1,3]dithian-2-yl}-6-methoxy-2-methyl-hexa-2,4-dienyl)-2-chloro-3-methoxy-phenyl]-methyl-carbamic acid methyl ester(141206-98-6)
• EPA Substance Registry System: [5-((2E,4E)-(R)-6-{2-[(E)-(2R,6S)-2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-8,8-diethoxy-oct-4-enyl]-[1,3]dithian-2-yl}-6-methoxy-2-methyl-hexa-2,4-dienyl)-2-chloro-3-methoxy-phenyl]-methyl-carbamic acid methyl ester(141206-98-6)

Safety Data

• Hazardous Substances Data: 141206-98-6(Hazardous Substances Data)

Upstream product

• 74510-48-8 [2-Chloro-5-((Z)-4-hydroxy-2-methyl-but-2-enyl)-3-methoxy-phenyl]-methyl-carbamic acid methyl ester 
• 141270-96-4 (R)-5,5-Diethoxy-pent-1-yn-3-ol 
• 141270-95-3 (S)-5,5-Diethoxy-pent-1-yn-3-ol 
• 141206-96-4 2-[(E)-(2R,6S)-2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-8,8-diethoxy-oct-4-enyl]-[1,3]dithiane-2-carbaldehyde 
• 141206-95-3 2-[(E)-(2R,6S)-2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-8,8-diethoxy-oct-4-enyl]-[1,3]dithiane 
• 141206-87-3 [5-((E)-5-Benzenesulfinyl-2-methyl-pent-2-enyl)-2-chloro-3-methoxy-phenyl]-methyl-carbamic acid methyl ester 
• 141206-85-1 [2-Chloro-5-((Z)-4,4-diethoxy-2-methyl-but-1-enyl)-3-methoxy-phenyl]-methyl-carbamic acid methyl ester 
• 141206-93-1 (2R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-1-[1,3]dithian-2-yl-8,8-diethoxy-oct-4-yn-2-ol 
• 141206-81-7 (2-Chloro-5-[1,3]dioxolan-2-yl-3-methoxy-phenyl)-carbamic acid methyl ester 
• 141206-82-8 (2-Chloro-5-[1,3]dioxolan-2-yl-3-methoxy-phenyl)-methyl-carbamic acid methyl ester 
• 141206-83-9 (2-Chloro-5-formyl-3-methoxy-phenyl)-methyl-carbamic acid methyl ester 
• 141206-94-2 (E)-(2R,6S)-1-[1,3]Dithian-2-yl-8,8-diethoxy-oct-4-ene-2,6-diol 
• 141206-79-3 2-(3-Methoxy-4-chloro-5-nitro-phenyl)-1, 3-dioxolane 
• 141206-80-6 2-(3-Amino-4-chloro-5-methoxy-phenyl)-1, 3-dioxolane 

Relevant articles and documents

TOTAL SYNTHESIS OF MAYTANSINOIDS. APPROACH TO 4,6-BISDEMETHYLMAYTANSINE AND 4-DEMETHYLMAYTANSINE

A convergent strategy was elaborated to synthesize maytansine 1 and maytansinoids modified on the carbon skeleton, especially 4-demethylmaytansine 2, 6-demethylmaytansine 3, 4,6-bisdemethylmaytansine 4.In this paper, the feasibility of the project was verified by the preparation of key intermediates for the synthesis of 4,6-bisdemethylmaytansine and 6-demethylmaytansine.The C-1-N open chain compound 18 in the 4,6-bisdemethyl series was obtained.