141222-03-9

Basic information

• Product Name: L-693,549
• Synonyms: L-693,549
• CAS NO: 141222-03-9
• Molecular Weight: 602.771
• Mol File: 141222-03-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-693,549(CAS DataBase Reference)
• NIST Chemistry Reference: L-693,549(141222-03-9)
• EPA Substance Registry System: L-693,549(141222-03-9)

Safety Data

• Hazardous Substances Data: 141222-03-9(Hazardous Substances Data)

Upstream product

• 141221-99-0 ((S)-1-{(2S,4R)-4-[4-(3-Hydroxy-propyl)-benzyl]-5-oxo-tetrahydro-furan-2-yl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester 
• 141222-24-4 4-(3-hydroxypropyl)benzyl bromide 
• 38628-53-4 3-<4-(hydroxymethyl)phenyl>propanol 

Relevant articles and documents

HIV-1 protease inhibitors based on hydroxyethylene dipeptide isosteres: An investigation into the role of the P1' side chain on structure-activity

A systematic investigation was undertaken to determine the role of the P1' sidechain in a series of hydroxyethylene isostere based inhibitors of HIV-1 protease. Substitution and homologation of the benzyl P1' side chain of the Phe-Phe isostere based pseudo peptides 1 (L-682,679) and 2 (L-685,434) with various heteroalkyl groups leads to a series of extremely potent inhibitors of the enzyme. Several examples of the most potent inhibitors were very effective in an ex vivo cell based viral spread assay using human H9 T- lymphocytes and the IIIb isolate of HIV-1. Compound 19 is 120 times more potent than 1 and 16 times more potent than 2 in inhibiting the spread of infection in this assay.