1412409-44-9

Basic information

• Product Name: 3,4-dichlorophenyl-α,β-dicyanoethyl propionate
• Synonyms: 3,4-dichlorophenyl-α,β-dicyanoethyl propionate
• CAS NO: 1412409-44-9
• Molecular Weight: 297.141
• Mol File: 1412409-44-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,4-dichlorophenyl-α,β-dicyanoethyl propionate(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dichlorophenyl-α,β-dicyanoethyl propionate(1412409-44-9)
• EPA Substance Registry System: 3,4-dichlorophenyl-α,β-dicyanoethyl propionate(1412409-44-9)

Safety Data

• Hazardous Substances Data: 1412409-44-9(Hazardous Substances Data)

Upstream product

• 773837-37-9 sodium cyanide 
• 55417-50-0 ethyl 2-cyano-3-(3,4-dichlorophenyl)-prop-2-enecarboxylate 
• 6287-38-3 3,4-dichlorobenzaldehyde 

Downstream Products

• 93553-81-2 3,4-dichlorophenylsuccinic acid 
• 157904-53-5 5,6-dichloroindan-1-carboxylic acid 

Relevant articles and documents

Synthesis of 5, 6-dichloroindan-1-acids and their tetrazolyl derivatives as analgesic and anti-inflammatory agents

Indan derivatives, namely, 5-(5′,6′-dichloroindan-1′-yl)- tetrazole (12a) and 5-(5′,6′-dichloroindan-1′-yl)- methyltetrazole (12b), were synthesized conveniently from 5,6-dichloroindan-1- carboxylic acid (9a) and 5,6- dichloroindan-1-acetic acid (9b), respectively, as potential analgesic and anti-inflammatory agents. The analgesic and anti-inflammatory properties of 9a, 9b, 12a and 12b were evaluated by the acetic acid induced writhing in Swiss albino mice and the carrageenan-induced rat paw edema models, respectively. Compounds 9a and 12a exhibited significant analgesic activity with the doses of 50 and 100 mg/kg body weight, comparable to that of the positive controls, phenylbutazone, indomethacin and aminopyrine. The anti-inflammatory potencies of 9a and 12a were also comparable to that of the positive control, phenylbutazone. Compounds 9b and 12b showed analgesic and anti-inflammatory activities, but were weaker than that of compounds 9a and 12a.