1412441-78-1

Basic information

• Product Name: C₈H₁₀ClN₃O
• CAS NO: 1412441-78-1
• Molecular Weight: 199.64
• Mol File: 1412441-78-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₈H₁₀ClN₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₈H₁₀ClN₃O(1412441-78-1)
• EPA Substance Registry System: C₈H₁₀ClN₃O(1412441-78-1)

Safety Data

• Hazardous Substances Data: 1412441-78-1(Hazardous Substances Data)

Upstream product

• 5439-11-2 2-bromo-N-(2'-chlorophenyl)acetamide 
• 95-51-2 o-chloroaniline 

Downstream Products

• 1412441-87-2 N-(2-chlorophenyl)-2-(2-(4-(dimethylamino)benzylidene)hydrazinyl)acetamide 
• 1412441-97-4 N-(2-chlorophenyl)-2-(3-(2,4-dichlorophenoxy)-2-(4-(dimethylamino)phenyl)-4-oxoazetidin-1-ylamino)acetamide 

Relevant articles and documents

Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole cryptosporidium parvum inosine 5′-monophosphate dehydrogenase (Cp IMPDH) inhibitors

Cryptosporidium inosine 5′-monophosphate dehydrogenase (CpIMPDH) has emerged as a therapeutic target for treating Cryptosporidium parasites because it catalyzes a critical step in guanine nucleotide biosynthesis. A 4-oxo-[1]benzopyrano[4,3-c]pyrazole derivative was identified as a moderately potent (IC50 = 1.5 μM) inhibitor of CpIMPDH. We report a SAR study for this compound series resulting in 8k (IC50 = 20 ± 4 nM). In addition, an X-ray crystal structure of CpIMPDH·IMP·8k is also presented.