141271-11-6

Basic information

• Product Name: (1S,4R)-4-[(2,5-DiaMino-6-chloro-4-pyriMidinyl)aMino]-2-cyclopentene-1-Methanol
• Synonyms: (1S,4R)-4-[(2,5-DiaMino-6-chloro-4-pyriMidinyl)aMino]-2-cyclopentene-1-Methanol;(1S-cis)-4-[(2,5-DiaMino-6-chloro-4-pyriMidinyl)aMino]-2-cyclopentene-1-Methanol
• CAS NO: 141271-11-6
• Molecular Formula: C₁₀H₁₃ClN₄O
• Molecular Weight: 256
• Product Categories: Bases & Related Reagents;Impurities;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 141271-11-6.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1S,4R)-4-[(2,5-DiaMino-6-chloro-4-pyriMidinyl)aMino]-2-cyclopentene-1-Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,4R)-4-[(2,5-DiaMino-6-chloro-4-pyriMidinyl)aMino]-2-cyclopentene-1-Methanol(141271-11-6)
• EPA Substance Registry System: (1S,4R)-4-[(2,5-DiaMino-6-chloro-4-pyriMidinyl)aMino]-2-cyclopentene-1-Methanol(141271-11-6)

Safety Data

• Hazardous Substances Data: 141271-11-6(Hazardous Substances Data)

Usage

Description

(1S,4R)-4-[(2,5-DiaMino-6-chloro-4-pyriMidinyl)aMino]-2-cyclopentene-1-Methanol is a chemical compound with a specific stereochemistry and molecular structure. It is characterized by its unique arrangement of atoms and functional groups, which contribute to its properties and potential applications.

Uses

Used in Pharmaceutical Industry:
(1S,4R)-4-[(2,5-DiaMino-6-chloro-4-pyriMidinyl)aMino]-2-cyclopentene-1-Methanol is used as an impurity in the production of Abacavir (A105000). Abacavir is an antiretroviral medication used to treat HIV-1 infection. The presence of this compound as an impurity is significant for ensuring the quality, safety, and efficacy of the final drug product.

Upstream product

• 56-05-3 2-Amino-4,6-dichloropyrimidine 
• 136522-35-5 (1R,4S)-1-amino-4-hydroxymethyl-2-cyclopentene 
• 182689-49-2 ((1S,4R,5S)-5-tert-Butoxy-4-hydroxymethyl-cyclopent-2-enyl)-methanol 
• 182689-66-3 ((1R,4S)-4-Hydroxymethyl-cyclopent-2-enyl)-carbamic acid methyl ester 
• 182689-64-1 Acetic acid (1S,4R)-4-methoxycarbonylamino-cyclopent-2-enylmethyl ester 
• 1026493-16-2 (1S,4S,5S)-4-Acetoxymethyl-5-tert-butoxy-cyclopent-2-enecarboxylic acid 
• 182689-61-8 Acetic acid (1S,4S,5S)-5-tert-butoxy-4-methoxycarbonylamino-cyclopent-2-enylmethyl ester 
• 182689-56-1 Acetic acid (1S,4R,5R)-5-tert-butoxy-4-hydroxymethyl-cyclopent-2-enylmethyl ester 
• 182689-48-1 Acetic acid (1S,4R,5S)-4-acetoxymethyl-5-tert-butoxy-cyclopent-2-enylmethyl ester 
• 130931-86-1 (-)-(1S,4R)-4-acetamidocyclopent-2-enylmethanol 
• 127061-46-5 methyl (+)-cis-4-acetamidocyclopent-2-enecarboxylate 
• 79200-56-9 (-)-2-azabicyclo[2.2.1]hept-5-en-3-one 
• 130931-84-9 (-)-(1S,4R)-4-aminocyclopent-2-ene-1-carboxylic acid hydrochloride 
• 229613-83-6 (–)-methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate hydrochloride 

Downstream Products

• 141271-13-8 (1S,4R)-4-(<2'-amino-6'-chloro-5'-<(4''-chlorophenyl)azo>pyrimidin-4'-yl>amino)cyclopent-2-enylmethanol 
• 141271-12-7 (1S, 4R)-(4-(2,5-diamino-6-chloro-4-pyrimidinyl)amino)-2-cyclopenten-1-methanol 
• 136522-33-3 (1S,4R)-4-[2-amino-6-chloro-9H-purin-9-yl]-2-cyclopentene-1-methanol 

Relevant articles and documents

Therapeutic nucleosides

The present invention relates to intermediates useful for the preparation of certain compounds, for example, purine carbocyclic nucleosides.

Antiviral combination comprising nucleoside analogs

Antiviral and antitumor compositions are disclosed comprising a mixture of AZT, ribavirin, d4T or CS-87 with a compound of general formula: STR1 wherein Z is H, OH or NH2, Y is CH, and X is selected from the group consisting of H, N(R)2, SR, OR or halogen, wherein R is H, lower(C1 -C4)alkyl, aryl or mixtures thereof, and the pharmaceutically-acceptable derivatives thereof.

Therapeutic nucleosides

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