1412905-15-7

Basic information

• Product Name: 2-(2-oxo-2H-chromen-4-yloxy)-N-(4-(3-oxomorpholino)phenyl)propanamide
• Synonyms: 2-(2-oxo-2H-chromen-4-yloxy)-N-(4-(3-oxomorpholino)phenyl)propanamide
• CAS NO: 1412905-15-7
• Molecular Weight: 408.411
• Mol File: 1412905-15-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-oxo-2H-chromen-4-yloxy)-N-(4-(3-oxomorpholino)phenyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-oxo-2H-chromen-4-yloxy)-N-(4-(3-oxomorpholino)phenyl)propanamide(1412905-15-7)
• EPA Substance Registry System: 2-(2-oxo-2H-chromen-4-yloxy)-N-(4-(3-oxomorpholino)phenyl)propanamide(1412905-15-7)

Safety Data

• Hazardous Substances Data: 1412905-15-7(Hazardous Substances Data)

Upstream product

• 312929-05-8 ethyl 2-[(2-oxo-2H-chromen-4-yl)oxy]propanoate 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 1412905-05-5 2-[(2-oxo-2H-chromen-4-yl)oxy]propanoic acid 
• 438056-69-0 4-(4-aminophenyl)morpholin-3-one 

Relevant articles and documents

Synthesis and pharmacological evaluation of N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide as cyclooxygenase inhibitors

A series of novel N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide derivatives were synthesized via converting the readily available 4-hydroxy coumarin to the corresponding ethyl 2-(2-oxo-2H-chromen-4-yloxy)propanoate followed by hydrolysis and then reacting with different substituted amines. The molecular structures of two representative compounds, that is, 3 and 5l were confirmed by single crystal X-ray diffraction study. All the compounds synthesized were evaluated for their cyclooxygenase (COX) inhibiting properties in vitro. The compound 5i showed balanced selectivity towards COX-2 over COX-1 inhibition and good docking scores when docked into the COX-2 protein.