141303-30-2Relevant articles and documents
Dynamic kinetic resolution of racemic β-haloalcohols: Direct access to enantioenriched epoxides
Haak, Robert M.,Berthiol, Florian,Jerphagnon, Thomas,Gayet, Arnaud J. A.,Tarabiono, Chiara,Postema, Christiaan P.,Ritleng, Vincent,Pfeffer, Michel,Janssen, Dick B.,Minnaard, Adriaan J.,Feringa, Ben L.,De Vries, Johannes G.
supporting information; body text, p. 13508 - 13509 (2009/02/06)
The direct chemo-enzymatic DKR of racemic β-haloalcohols is reported, yielding the corresponding optically active epoxides in a single step. The mutant haloalcohol dehalogenase HheC Cys153Ser Trp249Phe is used for the asymmetric ring closure, whereas racemization of the remaining enantiomer of the haloalcohol is achieved using the new iridacycle 3, one of the most effective racemization catalysts to date for β-haloalcohols. Copyright
Process for the preparation of optically active 2-halo-1-(substituted phenyl) ethanol
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, (2008/06/13)
The present invention provides an industrially advantageous process for the preparation of an optically active 2-halo-1-(substituted phenyl)ethanol useful as medicines, agricultural chemicals or as intermediates thereof; and a simple process for the prepa
