141376-11-6

Basic information

• Product Name: (4R,5R)-2-Phenyl-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide
• Synonyms: (4R,5R)-2-Phenyl-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide
• CAS NO: 141376-11-6
• Molecular Weight: 292.335
• Mol File: 141376-11-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4R,5R)-2-Phenyl-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5R)-2-Phenyl-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide(141376-11-6)
• EPA Substance Registry System: (4R,5R)-2-Phenyl-[1,3]dioxolane-4,5-dicarboxylic acid bis-dimethylamide(141376-11-6)

Safety Data

• Hazardous Substances Data: 141376-11-6(Hazardous Substances Data)

Upstream product

• 26549-65-5 N,N,N',N'-tetramethyl L-tartramide 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 35572-31-7 (4R,5R)-2-Phenyl-1,3-dioxolan-4,5-dicarbonsaeure-diethylester 
• 124-40-3 dimethyl amine 

Downstream Products

• 1070872-57-9 (-)-(2S,4R,5R)-5-benzoyl-2-phenyl-[1,3]dioxolane-4-carboxylic acid dimethylamide 
• 1070872-59-1 (+)-(2S,4R,5R)-2-phenyl-5-propionyl-[1,3]dioxolane-4-carboxylic acid dimethylamide 
• 141123-77-5 (4S,5S)-2-phenyl-4,5-bis((N,N-dimethylamino)methyl)-1,3-dioxolane 

Relevant articles and documents

Tartrate-Derived Aryl Aldehyde Acetals in the Asymmetric Directed Metalation of Chromium Tricarbonyl Arene Complexes

A series of three chromium tricarbonyl benzaldehyde acetal complexes were prepared from benzaldehyde diethyl acetal and (+)-diethyl tartrate.These compounds were ortho-lithiated by a number of bases, and the diastereoselectivity of lithiation was determined by quenching of the resulting anions with Me3SiCl.Complexes 1 and 2 were found to give moderate levels of diastereoselection, while the combination of complex 3 and 2.4 equiv of n-BuLi under equilibrating conditions gave an 86percent de of silylated products.Other electrophiles gave slightly higher de's (88percent to >/= 94percent), and all products derived from 3 were separable by column chromatography.Hydrolysis of the ortho-methylated product to the corresponding benzaldehyde complex (-)-21 as well as X-ray structural analysis of the trimethylsilylated complex demonstrated that preferential pro-R deprotonation had occurred.