141407-20-7Relevant articles and documents
Malaria causal prophylactic activity of imidazolidinedione derivatives
Guan, Jian,Wang, Xihong,Smith, Kirsten,Ager, Arba,Gettayacamin, Montip,Kyle, Dennis E.,Milhous, Wilbur K.,Kozar, Michael P.,Magill, Alan J.,Lin, Ai J.
, p. 6226 - 6231 (2007)
A series of acid-stable carboxamide derivatives of 2- guanidinoimidazolidinedione (5a-c and 6a-c) were prepared as potential malaria prophylactic and radical cure agents. The new compounds showed moderate to good causal prophylactic activity in mice infec
Unambiguous synthesis and prophylactic antimalarial activities of imidazolidinedione derivatives
Zhang, Quan,Guan, Jian,Sacci, John,Ager, Arba,Ellis, William,Milhous, Wilbur,Kyle, Dennis,Lin, Ai J.
, p. 6472 - 6481 (2007/10/03)
WR182393, a guanidinoimidazolidinedione derivatives with potent causal prophylactic antimalarial activity by intramuscular injection, was previouly prepared by treatment of chloroproguanil and diethyl oxalate, yielding a mixture of two closely related iso