14141-67-4

Basic information

• Product Name: 1,2,4,5-tetrazine-3,6-diylbis(phenylmethanol)
• CAS NO: 14141-67-4
• Molecular Formula: C₁₆H₁₄N₄O₂
• Molecular Weight: 294.308
• Mol File: 14141-67-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 572.2°C at 760 mmHg
• Flash Point: 299.9°C
• Density: 1.352g/cm³
• Vapor Pressure: 6.21E-14mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: 1,2,4,5-tetrazine-3,6-diylbis(phenylmethanol)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4,5-tetrazine-3,6-diylbis(phenylmethanol)(14141-67-4)
• EPA Substance Registry System: 1,2,4,5-tetrazine-3,6-diylbis(phenylmethanol)(14141-67-4)

Safety Data

• Hazardous Substances Data: 14141-67-4(Hazardous Substances Data)

Usage

Structure

Tetrazine derivative containing two phenylmethanol groups

Usage

Organic synthesis and chemical research

Applications

Building block for the synthesis of various organic molecules and pharmaceuticals

Potential

Development of new materials, dyes, and pigments

Suitability

Development of novel drugs and pharmaceutical compounds

Fields

Chemistry and materials science

Upstream product

• 78523-91-8 3,6-bis-(α-hydroxybenzyl)-1,2-dihydro-s-tetrazine 

Downstream Products

• 70753-21-8 mandelic acid-benzylidenehydrazide 
• 78523-92-9 4-hydroxy-3-(α-hydroxybenzyl)-4-phenyl-2-pyrazolin-5-one 
• 78523-91-8 3,6-bis-(α-hydroxybenzyl)-1,2-dihydro-s-tetrazine 

Relevant articles and documents

CLEAVABLE TETRAZINE USED IN BIO-ORTHOGONAL DRUG ACTIVATION

Disclosed is an advancement in provoked chemical cleavage. Thereby the invention provides the use of a diene as a chemically cleavable group attached to a Construct, and the use of a dienophile to provoke the release of the Construct by allowing the diene to react with a dienophile capable of undergoing an inverse electron demand Diels Alder reaction with the diene. The invention includes a kit for releasing a Construct CA bound to a Trigger TR, the kit comprising a tetrazine and a dienophile, wherein the Trigger is the tetrazine. The invention also includes the use of the formation of a pyridazine by reacting a tetrazine comprising a Construct CA bound thereto and a dienophile, as a chemical tool for the release, in a chemical, biological or physiological environment, of said Construct.