141412-69-3

Basic information

• Product Name: L-Glutamic acid, N-[4-[[(1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2 ,5-difluorobenzoyl]-, diethyl ester
• CAS NO: 141412-69-3
• Molecular Formula: C27H30F2N4O6
• Molecular Weight: 544.555
• Mol File: 141412-69-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Glutamic acid, N-[4-[[(1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2 ,5-difluorobenzoyl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Glutamic acid, N-[4-[[(1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2 ,5-difluorobenzoyl]-, diethyl ester(141412-69-3)
• EPA Substance Registry System: L-Glutamic acid, N-[4-[[(1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2 ,5-difluorobenzoyl]-, diethyl ester(141412-69-3)

Safety Data

• Hazardous Substances Data: 141412-69-3(Hazardous Substances Data)

Upstream product

• 7498-31-9 diethyl N-(2,5-difluoro-4-nitrobenzoyl)-L-glutamate 
• 141412-61-5 diethyl N-(4-amino-2,5-difluorobenzoyl)-L-glutamate 
• 116465-48-6 2,5‐difluoro‐4‐nitrobenzoic acid 
• 141412-60-4 1,4-difluoro-2-methyl-5-nitrobenzene 
• 452-67-5 1,4-difluoro-2-methylbenzene 
• 112888-43-4 4(3H)-oxo-6-(bromomethyl)-2-methyl quinazoline 
• 141412-63-7 diethyl N-(2,5-difluoro-4-(methylamino)benzoyl)-L-glutamate 

Downstream Products

• 141412-84-2 N-(2,5-difluoro-4-{N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino}benzoyl)-L-glutamic acid 

Relevant articles and documents

Quinazoline antifolate thymidylate synthase inhibitors: Difluoro- substituted benzene ring analogues

The synthesis of a series of new C2-methyl-N10-alkylquinazoline-based thymidylate synthase (TS) inhibitors containing difluorinated p-aminobenzoate rings is described. Derivatives of the N10-propargyl and N10- m