1414626-98-4

Basic information

• Product Name: 4-(2-(4-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzene-1,3-diol
• Synonyms: 4-(2-(4-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzene-1,3-diol
• CAS NO: 1414626-98-4
• Molecular Weight: 339.375
• Mol File: 1414626-98-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-(4-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzene-1,3-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-(4-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzene-1,3-diol(1414626-98-4)
• EPA Substance Registry System: 4-(2-(4-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzene-1,3-diol(1414626-98-4)

Safety Data

• Hazardous Substances Data: 1414626-98-4(Hazardous Substances Data)

Upstream product

• 1014-25-1 5-(4-methoxy-phenyl)-[1,3,4]thiadiazol-2-ylamine 
• 2491-39-6 2-bromo-2',4'-dihydroxyoacetophenone 
• 100-09-4 4-methoxybenzoic acid 

Relevant articles and documents

2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazoles: Search for anticancer agents

In this study, some novel 2,6-disubstituted imidazo[2,1-b][1,3,4] thiadiazoles 4 (a-i), 7 (a-p) and 11 (a-i) were synthesized from 5-substituted-1,3,4-thiadiazol-2-amine. The newly synthesized compounds 4a, 4b, 4c, 4e, 4g, 7j, 7l, 11b and 11c were evaluated in the National Cancer Institute for single dose in vitro primary cytotoxicity assay. Among the tested nine compounds, compound 4b (107166/760239) and 4c (107168/760240) were passed the criteria for activity in this assay and scheduled automatically for evaluation against the full panel of 60 human tumor cell lines at a minimum of five concentrations at 10-fold dilutions. 3-(2-(4-methoxyphenyl)imidazo[2,1-b][1,3,4] thiadiazol-6-yl)aniline (4c) exhibited significant in vitro anticancer activity against Non Small Cell Lung Cancer HOP-92 cell line (GI50: 0.114 μM) and Renal Cancer CAKI-1 cell line (GI50: 0.743 μM).