1414628-41-3

Basic information

• Product Name: tert-butyl [3-(2-(4-benzylpiperidin)acetyl)-1H-indol-5-yl]carbamate
• Synonyms: tert-butyl [3-(2-(4-benzylpiperidin)acetyl)-1H-indol-5-yl]carbamate
• CAS NO: 1414628-41-3
• Molecular Weight: 447.577
• Mol File: 1414628-41-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl [3-(2-(4-benzylpiperidin)acetyl)-1H-indol-5-yl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl [3-(2-(4-benzylpiperidin)acetyl)-1H-indol-5-yl]carbamate(1414628-41-3)
• EPA Substance Registry System: tert-butyl [3-(2-(4-benzylpiperidin)acetyl)-1H-indol-5-yl]carbamate(1414628-41-3)

Safety Data

• Hazardous Substances Data: 1414628-41-3(Hazardous Substances Data)

Upstream product

• 885273-73-4 tert-butyl N-(1H-indol-6-yl)carbamate 
• 31252-42-3 4-benzylpyperidine 
• 1414627-92-1 tert-butyl [3-(chloroacetyl)-1H-indol-5-yl]carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5318-27-4 6-amino-1H-indole 
• 5192-03-0 5-amino-1H-indole 

Downstream Products

• 1414628-64-0 C₂₃H₂₇N₃O₃S 
• 1414628-54-8 C₂₂H₂₅N₃O 

Relevant articles and documents

Synthesis and biological characterization of 3-substituted 1 H -indoles as ligands of GluN2B-containing N-methyl-d-aspartate receptors. Part 2

In the course of the identification of new indole derivatives targeting GluN2B-subunit-containing N-methyl-d-aspartate (NMDA) receptor, the (N-1H-indol-6-methanesulfonamide-3-yl)-2-(4-benzylpiperidin-1-yl)ethanone (10b) was identified as a potent ligand for this NMDA receptor subunit. It displays very high binding affinity (IC50 of 8.9 nmol) for displacement of [3H]ifenprodil, thus showing improved potency with respect to the previously reported analogues as confirmed by functional assay. This finding was consistent with the docking pose of compound 10b within the binding pocket localized in the GluN1-GluN2B subunit interface of NMDA receptor tetraheteromeric complex.