1414962-74-5

Basic information

• Product Name: 3,3,3-trifluoro-2-hydroxy-N-(4-methylbenzyl)-2-phenylpropanamide
• Synonyms: 3,3,3-trifluoro-2-hydroxy-N-(4-methylbenzyl)-2-phenylpropanamide
• CAS NO: 1414962-74-5
• Molecular Weight: 323.315
• Mol File: 1414962-74-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,3,3-trifluoro-2-hydroxy-N-(4-methylbenzyl)-2-phenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3,3-trifluoro-2-hydroxy-N-(4-methylbenzyl)-2-phenylpropanamide(1414962-74-5)
• EPA Substance Registry System: 3,3,3-trifluoro-2-hydroxy-N-(4-methylbenzyl)-2-phenylpropanamide(1414962-74-5)

Safety Data

• Hazardous Substances Data: 1414962-74-5(Hazardous Substances Data)

Upstream product

• 2947-61-7 (4-methylphenyl)acetonitrile 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 64-19-7 acetic acid 
• 39495-97-1 p-tolylmethyl isocyanide 
• 90609-66-8 N-(4-methylbenzyl)formamide 

Relevant articles and documents

Synthesis, crystal structure, DFT analysis and fungicidal activity of a novel series O-substituted trifluoroatrolactamide derivatives

A series of O-substituted trifluoroatrolactamide derivatives has been synthesized and fully characterized by 1H NMR, 13C NMR, 19F NMR, HRMS and X-ray diffraction analyses. The fungicidal activity of these compounds was evaluated and the results showed that some of them exhibited potent in?vitro fungicidal activity against Erysiphe graminis and Pyricularia oryzae. Their structure-property relationships were investigated using density functional theory calculations. The X-ray crystal structure of one of these compounds adopted a monoclinic space group with the following unit cell parameters: a?=?24.285 (13) ?, b?=?9.006 (5) ?, c?=?9.794 (5) ?, β?=?92.110 (9)o, V?=?2140.6 (19) ?3 and Z?=?4. A comparison of these experimental results with the theoretical values revealed that there was good agreement between the two sets of data. The subsequent biological evaluation of these compounds showed that some of them exhibited potent in?vitro fungicidal activity against Erysiphe graminis and Pyricularia oryzae.

Ultrasound-promoted sterically congested Passerini reactions under solvent-free conditions

A facile, efficient and environmentally-friendly protocol for the synthesis of α-acyloxy amides has been developed by ultrasound-promoted sterically congested Passerini reactions under solvent-free conditions. This method provides several advantages over current reaction methodologies including a simpler work-up procedure, shorter reaction times and higher yields.