1414963-82-8

Basic information

• Product Name: N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N′-(2-pyridinylmethyl)-urea
• Synonyms: N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N′-(2-pyridinylmethyl)-urea
• CAS NO: 1414963-82-8
• Molecular Formula: C13H11N5O3
• Molecular Weight: 285.25814
• Mol File: 1414963-82-8.mol
• Article Data: 0

Chemical Properties

• Appearance: white to beige/
• Density: 1.408±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble20mg/mL, clear
• PKA: 11.50±0.70(Predicted)
• CAS DataBase Reference: N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N′-(2-pyridinylmethyl)-urea(CAS DataBase Reference)
• NIST Chemistry Reference: N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N′-(2-pyridinylmethyl)-urea(1414963-82-8)
• EPA Substance Registry System: N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N′-(2-pyridinylmethyl)-urea(1414963-82-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 1414963-82-8(Hazardous Substances Data)

Usage

Description

1-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-3-(pyridin-2-ylmethyl)urea is a complex organic compound characterized by its unique molecular structure, which includes a urea group, a pyridine ring, and a furan-2-yl oxadiazole moiety. 1-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-3-(pyridin-2-ylmethyl)urea is of interest due to its potential applications in various fields, particularly in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
1-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-3-(pyridin-2-ylmethyl)urea is used as a pharmaceutical compound for its potential therapeutic properties. The compound's unique structure may allow it to interact with specific biological targets, making it a candidate for the development of new drugs.
Used in Chemical Research:
In the field of chemical research, 1-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-3-(pyridin-2-ylmethyl)urea can be used as a starting material or intermediate in the synthesis of more complex molecules. Its reactivity and functional groups may enable the creation of novel compounds with diverse applications.
Used in Antifibrotic Applications:
1-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-3-(pyridin-2-ylmethyl)urea, similar to NK 252, may be employed as an antifibrotic agent. By downregulating the expression of fibrogenic genes, it could potentially produce antifibrotic effects, which may be beneficial in treating conditions characterized by excessive fibrosis.
Used in Antioxidant Response Activation:
As a Nrf2 activator, 1-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-3-(pyridin-2-ylmethyl)urea may interact with the Nrf2-binding site of Keap1, leading to the activation of the NQO1-antioxidant response element. This property could be harnessed to develop treatments for conditions associated with oxidative stress or to enhance the body's natural antioxidant defenses.

references

[1]. shimozono r, asaoka y, yoshizawa y, et al. nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. mol pharmacol. 2013 jul;84(1):62-70.[2]. kiue a, sano t, naito a, et al. reversal by two dihydropyridine compounds of resistance to multiple anticancer agents in mouse p388 leukemia in vivo and in vitro. jpn j cancer res. 1990 oct;81(10):1057-64.