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1415000-05-3

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1415000-05-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1415000-05-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,1,5,0,0 and 0 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1415000-05:
(9*1)+(8*4)+(7*1)+(6*5)+(5*0)+(4*0)+(3*0)+(2*0)+(1*5)=83
83 % 10 = 3
So 1415000-05-3 is a valid CAS Registry Number.

1415000-05-3Downstream Products

1415000-05-3Relevant articles and documents

Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity

Guo, Di-Liang,Zhang, Xing-Jie,Wang, Rui-Rui,Zhou, Yu,Li, Zeng,Xu, Jin-Yi,Chen, Kai-Xian,Zheng, Yong-Tang,Liu, Hong

, p. 7114 - 7118 (2013/01/15)

A series of 5,6-dihydroxypyrimidine analogs were synthesized and evaluated for their anti-HIV activity in vitro. Among all of the analogs, several compounds exhibited significant anti-HIV activity, especially 1b and 1e, which showed the most potent anti-HIV activity with EC50 values of 0.14 and 0.15 μM, and TI (therapeutic index) values of >300 and >900, respectively. Further docking studies revealed that the representative compounds 1e and 3a could meet the HIV-1 integrase inhibition minimal requirements of a chelating domain (two metal ions) and an aromatic domain (π-π stacking interactions).

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