14151-88-3

Basic information

• Product Name: BENZO[F][1,4]OXAZEPINE-3,5-DIONE
• Synonyms: AKOS AU36-M170;BENZO[F][1,4]OXAZEPINE-3,5-DIONE;Benzo[f][1;Benzo[f][1,4]oxazepine-3,5(2H,4H)-dione
• CAS NO: 14151-88-3
• Molecular Formula: C₉H₇NO₃
• Molecular Weight: 177.16
• Mol File: 14151-88-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BENZO[F][1,4]OXAZEPINE-3,5-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZO[F][1,4]OXAZEPINE-3,5-DIONE(14151-88-3)
• EPA Substance Registry System: BENZO[F][1,4]OXAZEPINE-3,5-DIONE(14151-88-3)

Safety Data

• Hazardous Substances Data: 14151-88-3(Hazardous Substances Data)

Usage

General Description

BENZO[F][1,4]OXAZEPINE-3,5-DIONE is a chemical compound with a molecular formula C13H6N2O3. It belongs to the oxazepine family and is a heterocyclic compound containing a nitrogen and oxygen atom in its ring structure. BENZO[F][1,4]OXAZEPINE-3,5-DIONE is known for its potential pharmaceutical applications, particularly in the field of medicinal chemistry. It is used for the synthesis of various drugs and has shown potential in the treatment of various medical conditions. Its unique structural properties and reactivity make it a valuable molecule in organic chemistry and drug discovery research.

Upstream product

• 25395-22-6 2-(2-carbamoylphenoxy)acetic acid 
• 90074-90-1 2-(ethoxycarbonylmethyloxy)benzamide 
• 65-45-2 salicylamide 

Downstream Products

• 131112-58-8 4-[4-[4-(2-pyrimidinyl)piperazin-1-yl]butyl]-1,4-benzoxazepine-3,5(2H,4H)-dione 
• 182415-09-4 Piclozotan 

Relevant articles and documents

Synthesis, SAR studies, and evaluation of 1,4-benzoxazepine derivatives as selective 5-HT1A receptor agonists with neuroprotective effect: Discovery of Piclozotan

A new series of 1,4-benzoxazepine derivatives was designed, synthesized, and evaluated for binding to 5-HT1A receptor and cerebral anti-ischemic effect. A lot of compounds exhibited nanomolar affinity for 5-HT1A receptor with good selectivity over both dopamine D 2 and α1-adrenergic receptors. Among these compounds, 3-chloro-4-[4-[4-(2-pyridinyl)-1,2,3,6-tetrahydropyridin-1-yl]butyl]- 1, 4-benzoxazepin-5(4H)-one (50: SUN N4057 (Piclozotan) as 2HCl salt) showed remarkable neuroprotective activity in a transient middle cerebral artery occlusion (t-MCAO) model.

Synthesis of 1,4-benzonazepine-3,5(2H,4H)-dione from salicylamide [9]

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ON SOME NEW ALPHA-ISOBUTYRIC DERIVATIVES. IV.

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