1415149-83-5Relevant articles and documents
Structure-activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3- c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action
Thur, Yithachu,Bhalerao, Amit,Munshi, Zaki,Pansare, Nisha,Mann, Klaus,Hanauer, Guido,Kley, Hans-Peter,Nappe, Sandra,Weiss-Haljiti, Cornelia,Ostermann, Claude,Zitt, Christof,Schaefer, Michaela,Mondal, Dibyendu,Ali Siddiki, Afsar,Armugam, Velavan,Gudaghe, Vinod,Gupta, Mahendra,Rayudu, Pramila,Dautzenberg, Frank M.,Das Sarma, Koushik
, p. 7314 - 7321 (2013/02/21)
SAR studies were performed on a series of 2-arylamido-5,7-dihydro-4H- thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists. Starting from a HTS hit both potency and selectivity could be improved. Modifications to the thiophene fusion and C-3 amides were studied. A representative compound 3t produced analgesia when dosed orally in inflammatory pain models of writhing and carrageenan-induced allodynia.