141543-65-9 Usage
Description
1-(5-Isoquinolinesulfonyl)-3-methylpiperazine Hydrochloride is a chemical compound that serves as a selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases. It is characterized by its off-white solid appearance and is utilized in various applications across different industries due to its unique properties.
Uses
Used in Pharmaceutical Industry:
1-(5-Isoquinolinesulfonyl)-3-methylpiperazine Hydrochloride is used as a selective inhibitor for protein kinase C or cyclic-nucleotide-dependent protein kinases. Its application in this industry is due to its ability to modulate the activity of these kinases, which play a crucial role in various cellular processes and are often implicated in the development of various diseases.
Used in Research and Development:
In the field of research and development, 1-(5-Isoquinolinesulfonyl)-3-methylpiperazine Hydrochloride is used as a valuable tool for studying the functions and mechanisms of protein kinase C and cyclic-nucleotide-dependent protein kinases. Its selective inhibition properties allow researchers to investigate the roles of these kinases in cellular signaling pathways and their potential as therapeutic targets for various diseases.
Used in Drug Discovery and Development:
1-(5-Isoquinolinesulfonyl)-3-methylpiperazine Hydrochloride is also used in drug discovery and development as a potential lead compound for the development of new therapeutic agents targeting protein kinase C or cyclic-nucleotide-dependent protein kinases. Its selective inhibition of these kinases makes it a promising starting point for the design and synthesis of novel drugs with improved efficacy and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 141543-65-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,5,4 and 3 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 141543-65:
(8*1)+(7*4)+(6*1)+(5*5)+(4*4)+(3*3)+(2*6)+(1*5)=109
109 % 10 = 9
So 141543-65-9 is a valid CAS Registry Number.
InChI:InChI=1/C14H17N3O2S.ClH/c1-11-10-17(8-7-16-11)20(18,19)14-4-2-3-12-9-15-6-5-13(12)14;/h2-6,9,11,16H,7-8,10H2,1H3;1H
141543-65-9Relevant articles and documents
5-Isoquinolinesulfonamide derivatives. III. Synthesis and vasodilatory activity of 1-(5-isoquinolinesulfonyl)piperazine derivatives
Morikawa,Sone,Asano
, p. 770 - 773 (2007/10/02)
On the basis of a hypothesis that cyclization and alkylation of the diamine part in formula 1 may give highly active compounds, a new series of 5-isoquinolinesulfonamide derivatives, shown as formula 2, were prepared from cyclic diamines. Their vasodilatory effects were subsequently evaluated in vivo according to the increase in arterial blood flow after the formulas were injected locally to the femoral and/or vertebral arteries of dogs. Cyclization of the diamine structure in formula 1 gave very potent vasodilators: 6 and 14. Acylation and sulfonylation of terminal amino nitrogen afforded much less potent compounds. In contrast to the hypothesis, alkylation on the ring carbon and the terminal nitrogen of the cyclic amine afforded less active compounds except for compound 11. The most active compounds, 6, 11 and 14, showed more potent vasodilatory effects and more selective activity to the vertebral artery than either trapidil or diltiazem.
