141544-16-3

Basic information

• Product Name: 2-Propenamide, N-methyl-3-(4-nitrophenyl)-, (E)-
• CAS NO: 141544-16-3
• Molecular Formula: C10H10N2O3
• Molecular Weight: 206.201
• Mol File: 141544-16-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Propenamide, N-methyl-3-(4-nitrophenyl)-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenamide, N-methyl-3-(4-nitrophenyl)-, (E)-(141544-16-3)
• EPA Substance Registry System: 2-Propenamide, N-methyl-3-(4-nitrophenyl)-, (E)-(141544-16-3)

Safety Data

• Hazardous Substances Data: 141544-16-3(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 72563-39-4 diethyl <(N-methylcarbamoyl)methyl>phosphonate 
• 74-89-5 methylamine 
• 61921-33-3 p-nitrocinnamoyl chloride 
• 619-89-6 p-nitrocinnamic acid 
• 141544-10-7 4-Methyl-2-(4-nitro-phenyl)-6-oxo-cyclohex-4-ene-1,3-dicarboxylic acid bis-methylamide 
• 132599-15-6 4-hydroxy-2-(4-nitrophenyl)-N,N',4-trimethyl-6-oxocyclohexane-1,3-dicarboxamide 
• 22440-58-0 (E)-4-nitrocinnamic acid chloride 

Downstream Products

• 1598408-52-6 C₁₀H₁₂N₂O 
• 705256-69-5 3-(4-aminophenyl)-N-methylpropanamide 
• 1598408-26-4 1-(4-((E)-2-(methylcarbamoyl)vinyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea 
• 1598408-31-1 1-(4-(2-(methylcarbamoyl)ethyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea 

Relevant articles and documents

Design, synthesis and evaluation of novel diaryl urea derivatives as potential antitumor agents

A novel series of diaryl ureas containing different linker groups were designed and synthesized. Their in vitro antitumor activity against MX-1, A375, HepG2, Ketr3 and HT-29 was evaluated using the standard MTT assay. Compounds having a rigid linker group such as vinyl, ethynyl and phenyl showed significant inhibitory activity against a variety of cancer cell lines. Specifically, compound 23 with a phenyl linker group demonstrated broad-spectrum antitumor activity with IC50 values of 5.17-6.46 μM against five tested tumor cell lines. Compound 23 is more potent than reference drug sorafenib (8.27-15.2 μM), representing a promising lead for further optimization.

An Unusual Ring-Cleavage of 2,4-Di-N-methylcarbamoylcyclohexanones into Glutaconimide and Cinnamamides

3-Aryl-5-hydroxy-5-methyl-2,4-di-N-methylcarbamoylcyclohexanones (1a-h) under acidic and basic conditions underwent ring-cleavage to give 1,4-dimethylglutaconimide (3) and substituted N-methylcinnamamides (4a-h).The probable mechanism for the formation of