1415651-26-1

Basic information

• Product Name: 4-acetamidophenyl-2-[{4-{(4-acetamidophenoxy)carbonyl}phenyl}{2-(nitrooxy)ethyl}amino] benzoate
• Synonyms: 4-acetamidophenyl-2-[{4-{(4-acetamidophenoxy)carbonyl}phenyl}{2-(nitrooxy)ethyl}amino] benzoate
• CAS NO: 1415651-26-1
• Molecular Weight: 612.596
• Mol File: 1415651-26-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-acetamidophenyl-2-[{4-{(4-acetamidophenoxy)carbonyl}phenyl}{2-(nitrooxy)ethyl}amino] benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-acetamidophenyl-2-[{4-{(4-acetamidophenoxy)carbonyl}phenyl}{2-(nitrooxy)ethyl}amino] benzoate(1415651-26-1)
• EPA Substance Registry System: 4-acetamidophenyl-2-[{4-{(4-acetamidophenoxy)carbonyl}phenyl}{2-(nitrooxy)ethyl}amino] benzoate(1415651-26-1)

Safety Data

• Hazardous Substances Data: 1415651-26-1(Hazardous Substances Data)

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 1415651-21-6 C₃₂H₂₈ClN₃O₆ 
• 1415651-16-9 C₃₀H₂₅N₃O₆ 
• 88-67-5 2-Iodobenzoic acid 
• 17332-57-9 N-(4-carboxyphenyl)anthranilic acid 

Relevant articles and documents

Synthesis and investigation of anti-inflammatory activity of novel nitric oxide donating hybrid drugs

A small library of nitric oxide donating groups, 4-acetamidophenyl-2-[{2- (nitrooxy)ethyl}(phenyl) amino]benzoate (5a-e) possessing a variety of substituents (-H, -NO2, -CH3, -acetamidophenyl, -SO 2NH2) attached to the fourth position of phenyl ring were synthesized and evaluated for anti-inflammatory, analgesic and ulcerogenic potential. Structure-activity relationship data showed that the 2-phenylaminobenzoic acid skeleton is required for selective COX-2 inhibition. Among all compounds 4-acetamidophenyl-2-[{2-(nitrooxy)ethyl}(phenyl)amino] benzoate (5a) has shown potent anti-inflammatory activity while 4-acetamidophenyl-2-[{4-{(4-acetamidophenoxy)carbonyl} phenyl}{2-(nitrooxy) ethyl}amino]benzoate (5d) has shown potent analgesic activity compared to standard drug diclofenac.