1415669-38-3

Basic information

• Product Name: C₁₅H₁₅N₃O₃S₂
• Synonyms: C₁₅H₁₅N₃O₃S₂
• CAS NO: 1415669-38-3
• Molecular Weight: 349.434
• Mol File: 1415669-38-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₅N₃O₃S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₅N₃O₃S₂(1415669-38-3)
• EPA Substance Registry System: C₁₅H₁₅N₃O₃S₂(1415669-38-3)

Safety Data

• Hazardous Substances Data: 1415669-38-3(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 4392-54-5 4-aminosulfonylphenylhydrazine 
• 21305-93-1 1-benzylidene-2-(4-(aminosulfonyl)phenyl)hydrazine 
• 68-11-1 mercaptoacetic acid 

Relevant articles and documents

Synthesis of sulfonamides bearing 1,3,5-triarylpyrazoline and 4-thiazolidinone moieties as novel antimicrobial agents

Two series of sulfonamides were synthesized from 4-hydrazinylben-zenesulfonamide as the key starting material. 1,3,5-Triarylpyrazoline sulfonamides (2a-i) were obtained by cyclocondensation of various chalcones in 53-64 % yields, while 4-thiazolidinone derivatives (4a-e) were synthesized by cyclocondensation between mercaptoacetic acid and different phenylhydrazones in 43-62 % yields. The synthesized compounds were characterized based on FTIR, 1H-NMR, 13C-NMR and HRMS data. The sulfonamides were evaluated for their in vitro antimicrobial activities against four bacterial strains (E. coli, P. aeruginosa, B. subtillis and S aureus), two filamentous fungal strains (A. Niger and F. oxysporum) and two yeast strains (C. albicans and S. cerevisiae). Seven pyrazolines, 2a-c and 2e-h, exhibited significant inhibition of different microbial strains. Among them, compound 2b displayed good antifungal activity against A. Niger (MIC value at 12.5 μg mL-1) over the reference drug.