1415703-89-7

Basic information

• Product Name: N-(4-((2,2,2-trifluoroethyl)thio)phenyl) acetamide
• Synonyms: N-(4-((2,2,2-trifluoroethyl)thio)phenyl) acetamide
• CAS NO: 1415703-89-7
• Molecular Weight: 249.257
• Mol File: 1415703-89-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(4-((2,2,2-trifluoroethyl)thio)phenyl) acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-((2,2,2-trifluoroethyl)thio)phenyl) acetamide(1415703-89-7)
• EPA Substance Registry System: N-(4-((2,2,2-trifluoroethyl)thio)phenyl) acetamide(1415703-89-7)

Safety Data

• Hazardous Substances Data: 1415703-89-7(Hazardous Substances Data)

Upstream product

• 103-84-4 Acetanilid 
• 860577-22-6 acylaminophenylallylsulfide 
• 373-88-6 2,2,2-trifluroethylamine hydrochloride 
• 1126-81-4 4-acetamidothiophenol 
• 75-89-8 2,2,2-trifluoroethanol 

Relevant articles and documents

Metal-Free Electrophilic Trifluoroethylthiolation with NaSO2CH2CF3

Metal-free trifluoroethylthiolation with fluorinated sulfinate salt NaSO2CH2CF3 under reductive conditions has been developed. The strategy enables the installation of the SCH2CF3 moiety efficiently to form a number of unexplored stable trifluoroethylthiolated heterocycles, arenes, and thiols, which have the potential to be a new series of fluorine-containing chemical entities for medicinal chemists.

New sulfuryl fluoride-derived alkylating reagents for the 1,1-dihydrofluoroalkylation of thiols

Herein, we report a new method for the one-pot synthesis of 1,1-dihydrofluoroalkyl sulfides by bubbling sulfuryl fluoride (SO2F2) through a solution of the corresponding alcohol and thiol. The reaction proceeds through a new class of bis(1,1-dihydrofluoroalkyl) sulfate reagents, to afford the desired 1,1-dihydrofluoroalkyl sulfides in 55-90% isolated yields. The bis(1,1-dihydrofluoroalkyl) sulfates are highly chemoselective for thiol alkylation, and are unreactive with competing, unprotected nucleophiles, including amines, alcohols, and carboxylic acids.