1415914-98-5

Basic information

• Product Name: (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-2,2,4-trifluoro-3-(2-fluorophenyl)butanoate
• Synonyms: (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-2,2,4-trifluoro-3-(2-fluorophenyl)butanoate
• CAS NO: 1415914-98-5
• Molecular Weight: 383.407
• Mol File: 1415914-98-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-2,2,4-trifluoro-3-(2-fluorophenyl)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-2,2,4-trifluoro-3-(2-fluorophenyl)butanoate(1415914-98-5)
• EPA Substance Registry System: (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-2,2,4-trifluoro-3-(2-fluorophenyl)butanoate(1415914-98-5)

Safety Data

• Hazardous Substances Data: 1415914-98-5(Hazardous Substances Data)

Upstream product

• 218771-68-7 1-(2-fluorophenyl)-2-hydroxyethan-1-one 
• 1402412-84-3 2-fluoro-1-(2-fluorophenyl)ethan-1-one 

Downstream Products

• 1415914-91-8 (S)-N-(3-(2-amino-5,5-difluoro-4-(fluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide 
• 1415915-03-5 (S)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-fluoromethyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine 
• 1415915-02-4 (S)-5,5-difluoro-4-fluoromethyl-4-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamine 
• 1415915-01-3 (S)-5,5-difluoro-4-fluoromethyl-4-(2-fluoro-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamine 
• 1415915-00-2 (S)-3-amino-2,2,4-trifluoro-3-(2-fluoro-phenyl)-butan-1-ol 
• 1415914-99-6 2-methyl-propane-2-sulfinic acid [(S)-2,2-difluoro-1-fluoromethyl-1-(2-fluoro-phenyl)-3-hydroxy-propyl]-amide 

Relevant articles and documents

β-secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease

An extensive fluorine scan of 1,3-oxazines revealed the power of fluorine(s) to lower the pKa and thereby dramatically change the pharmacological profile of this class of BACE1 inhibitors. The CF3 substituted oxazine 89, a potent and