1416173-86-8

Basic information

• Product Name: tert-butyl 2-{3-[3-fluoro-4-(methanesulfonyl)phenoxy]propyl}-7-azaspiro[3.5]nonane-7-carboxylate
• Synonyms: tert-butyl 2-{3-[3-fluoro-4-(methanesulfonyl)phenoxy]propyl}-7-azaspiro[3.5]nonane-7-carboxylate
• CAS NO: 1416173-86-8
• Molecular Weight: 455.591
• Mol File: 1416173-86-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-{3-[3-fluoro-4-(methanesulfonyl)phenoxy]propyl}-7-azaspiro[3.5]nonane-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-{3-[3-fluoro-4-(methanesulfonyl)phenoxy]propyl}-7-azaspiro[3.5]nonane-7-carboxylate(1416173-86-8)
• EPA Substance Registry System: tert-butyl 2-{3-[3-fluoro-4-(methanesulfonyl)phenoxy]propyl}-7-azaspiro[3.5]nonane-7-carboxylate(1416173-86-8)

Safety Data

• Hazardous Substances Data: 1416173-86-8(Hazardous Substances Data)

Upstream product

• 859538-50-4 3-fluoro-4-(methanesulfonyl)phenol 
• 1346556-73-7 tert-butyl 2-formyl-7-azaspiro[3.5]nonane-7-carboxylate 
• 203661-69-2 tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate 

Downstream Products

• 1416175-50-2 propan-2-yl 2-{3-[3-fluoro-4-(methanesulfonyl)phenoxy]propyl}-7-azaspiro[3.5]nonane-7-carboxylate 
• 1416175-52-4 1-methylcyclopropyl 2-{3-[3-fluoro-4-(methanesulfonyl)phenoxy]propyl}-7-azaspiro[3.5]nonane-7-carboxylate 
• 1416175-71-7 cyclopentyl 2-{3-[3-fluoro-4-(methanesulfonyl)phenoxy]propyl}-7-azaspiro[3.5]nonane-7-carboxylate 
• 1416175-72-8 2,2-dimethylpropyl 2-{3-[3-fluoro-4-(methanesulfonyl)phenoxy]propyl}-7-azaspiro[3.5]nonane-7-carboxylate 
• 1416175-33-1 7-(5-ethylpyrimidin-2-yl)-2-{3-[3-fluoro-4-(methanesulfonyl)phenoxy]propyl}-7-azaspiro[3.5]nonane 

Relevant articles and documents

Design, synthesis and biological evaluation of novel 7-azaspiro[3.5]nonane derivatives as GPR119 agonists

The design and synthesis of a novel class of 7-azaspiro[3.5]nonane GPR119 agonists are described. In this series, optimization of the right piperidine N-capping group (R2) and the left aryl group (R3) led to the identification of compound 54g as a potent GPR119 agonist. Compound 54g showed a desirable PK profile in Sprague-Dawley (SD) rats and a favorable glucose lowering effect in diabetic rats.