1416176-14-1Relevant articles and documents
Design, synthesis and biological evaluation of novel 7-azaspiro[3.5]nonane derivatives as GPR119 agonists
Matsuda, Daisuke,Kawamura, Madoka,Kobashi, Yohei,Shiozawa, Fumiyasu,Suga, Youichirou,Fusegi, Keiko,Nishimoto, Shinichi,Kimura, Kayo,Miyoshi, Masako,Takayama, Noriko,Kakinuma, Hiroyuki,Ohtake, Norikazu
, p. 1832 - 1847 (2018/03/01)
The design and synthesis of a novel class of 7-azaspiro[3.5]nonane GPR119 agonists are described. In this series, optimization of the right piperidine N-capping group (R2) and the left aryl group (R3) led to the identification of compound 54g as a potent GPR119 agonist. Compound 54g showed a desirable PK profile in Sprague-Dawley (SD) rats and a favorable glucose lowering effect in diabetic rats.
SUBSTITUTED SPIROPIPERIDINYL COMPOUNDS USEFUL AS GPR120 AGONISTS
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Page/Page column 56, (2014/05/07)
The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.