1416439-28-5

Basic information

• Product Name: C₁₅H₉FN₂O₃
• CAS NO: 1416439-28-5
• Molecular Weight: 284.246
• Mol File: 1416439-28-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₉FN₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₉FN₂O₃(1416439-28-5)
• EPA Substance Registry System: C₁₅H₉FN₂O₃(1416439-28-5)

Safety Data

• Hazardous Substances Data: 1416439-28-5(Hazardous Substances Data)

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1999-00-4 ethyl 3-(4'-fluorophenyl)-3-oxopropionate 

Downstream Products

• 423182-97-2 C₂₅H₁₈ClFN₆ 
• 1393883-04-9 C₂₅H₁₉FN₆ 
• 423183-09-9 C₂₅H₁₈F₂N₆ 
• 423183-39-5 C₂₆H₂₁FN₆O 
• 1393883-05-0 C₂₄H₁₈FN₇ 
• 1393883-06-1 C₂₂H₂₁FN₆ 
• 1393883-07-2 C₂₁H₁₉FN₆ 
• 1393883-08-3 C₂₀H₁₇FN₆ 
• 1393883-10-7 C₂₃H₁₉FN₈ 
• 1416440-17-9 C₁₅H₈ClFN₂O₂ 
• 423183-90-8 2-(4-fluorophenyl)quinoline-4,6-diamine 
• 423182-56-3 C₂₅H₁₈ClFN₆ 
• 1393883-14-1 C₂₆H₂₁FN₆ 
• 423182-58-5 C₂₆H₁₈F₄N₆ 

Relevant articles and documents

Quinolinyl pyrimidines: Potent inhibitors of NDH-2 as a novel class of anti-TB agents

NDH-2 is an essential respiratory enzyme in Mycobacterium tuberculosis (Mtb), which plays an important role in the physiology of Mtb. Herein, we present a target-based effort to identify a new structural class of inhibitors for NDH-2. High-throughput screening of the AstraZeneca corporate collection resulted in the identification of quinolinyl pyrimidines as the most promising class of NDH-2 inhibitors. Structure-activity relationship studies showed improved enzyme inhibition (IC50) against the NDH-2 target, which in turn translated into cellular activity against Mtb. Thus, the compounds in this class show a good correlation between enzyme inhibition and cellular potency. Furthermore, early ADME profiling of the best compounds showed promising results and highlighted the quinolinyl pyrimidine class as a potential lead for further development.