1416512-45-2

Basic information

• Product Name: C₂₆H₂₈O₅
• Synonyms: C₂₆H₂₈O₅
• CAS NO: 1416512-45-2
• Molecular Weight: 420.505
• Mol File: 1416512-45-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₂₈O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₂₈O₅(1416512-45-2)
• EPA Substance Registry System: C₂₆H₂₈O₅(1416512-45-2)

Safety Data

• Hazardous Substances Data: 1416512-45-2(Hazardous Substances Data)

Upstream product

• 1416512-12-3 4-hydroxy-3-{3-[5-hydroxy-2-methyl-2-(4-methyl-pent-3-enyl)-2H-chromen-6-yl]-3-oxopropenyl}-benzaldehyde 
• 31771-72-9 1-(5-hydroxy-2-methyl-2-(4-methylpent-3-enyl)-2H-chromen-6-yl)ethanone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 7549-37-3 citral dimethyl acetal 

Relevant articles and documents

Synthesis and insight into the structure-activity relationships of chalcones as antimalarial agents

Licochalcone A (I), isolated from the roots of Chinese licorice, is the most promising antimalarial compound reported so far. In continuation of our drug discovery program, we isolated two similar chalcones, medicagenin (II) and munchiwarin (III), from Crotalaria medicagenia, which exhibited antimalarial activity against Plasmodium falciparum. A library of 88 chalcones were synthesized and evaluated for their in vitro antimalarial activity. Among these, 67, 68, 74, 77, and 78 exhibited good in vitro antimalarial activity against P. falciparum strains 3D7 and K1 with low cytotoxicity. These chalcones also showed reduction in parasitemia and increased survival time of Swiss mice infected with Plasmodium yoelii (strain N-67). Pharmacokinetic studies indicated that low oral bioavailability due to poor ADME properties. Molecular docking studies revealed the binding orientation of these inhibitors in active sites of falcipain-2 (FP-2) enzyme. Compounds 67, 68, and 78 showed modest inhibitory activity against the major hemoglobin degrading cysteine protease FP-2.