141666-91-3

Basic information

• Product Name: Benzenesulfonamide, N-[2-(4-chlorophenyl)ethyl]-4-methyl-
• CAS NO: 141666-91-3
• Molecular Formula: C15H16ClNO2S
• Molecular Weight: 309.817
• Mol File: 141666-91-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-[2-(4-chlorophenyl)ethyl]-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-[2-(4-chlorophenyl)ethyl]-4-methyl-(141666-91-3)
• EPA Substance Registry System: Benzenesulfonamide, N-[2-(4-chlorophenyl)ethyl]-4-methyl-(141666-91-3)

Safety Data

• Hazardous Substances Data: 141666-91-3(Hazardous Substances Data)

Upstream product

• 140-53-4 p-chlorobenzyl cyanide 
• 159690-31-0 1-p-Toluolsulfonyl-1-phenethyl-hydrazin 
• 151259-26-6 C₁₉H₃₄N₂O₂S 
• 146404-40-2 1-tosyl-1-hexadecylhydrazine 
• 141666-87-7 1-Tosyl-1-<2-(4-methoxyphenyl)ethyl>hydrazine 
• 141666-92-4 4-methyl-N-[2-(4-methoxyphenyl)ethyl]benzenesulfonamide 
• 18049-99-5 N-hexadecyl-p-toluenesulfonamide 
• 1635-09-2 N-dodecyl-4-methylbenzenesulfonamide 
• 5450-75-9 4-methyl-N-(2-phenylethyl)benzenesulfonamide 
• 536-57-2 p-toluene sulfinic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 156-41-2 4-chlorophenylethylamine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 6529-53-9 1-(2-bromoethyl)-4-chlorobenzene 
• 5450-75-9 4-methyl-N-(2-phenylethyl)benzenesulfonamide 
• 1635-09-2 N-dodecyl-4-methylbenzenesulfonamide 
• 18049-99-5 N-hexadecyl-p-toluenesulfonamide 
• 1950-69-2 toluene-p-sulfonyl bromide 
• 141666-92-4 4-methyl-N-[2-(4-methoxyphenyl)ethyl]benzenesulfonamide 
• 141666-87-7 1-Tosyl-1-<2-(4-methoxyphenyl)ethyl>hydrazine 
• 146404-40-2 1-tosyl-1-hexadecylhydrazine 
• 98-59-9 p-toluenesulfonyl chloride 
• 151259-26-6 C₁₉H₃₄N₂O₂S 
• 159690-31-0 1-p-Toluolsulfonyl-1-phenethyl-hydrazin 
• 156-41-2 4-chlorophenylethylamine 
• 146404-41-3 C₁₅H₁₇ClN₂O₂S 
• 32327-70-1 1-chloro-4-(2-chloroethyl)benzene 

Relevant articles and documents

Method for preparing lorcaserin

The invention discloses a method for preparing lorcaserin. Specifically, the method comprises the steps: taking p-chlorophenylacetonitrile as an initial raw material, preparing p-chlorophenylethylamine through reduction; carrying out a reaction with p-toluenesulfonyl chloride to form an amino occupying intermediate; enabling the intermediate to carry out a reaction with monochloroacetone under analkaline condition to form N-(2-(4-chlorphenyl)ethyl)-4-methyl-N-(2-propionyl)benzenesulfonamide, and then carrying out reduction, chlorination, p-toluenesulfonyl removal and intramolecular Friedel-Crafts alkylation to synthesize 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzoazepine, carrying out L-(+)-tartaric acid resolution and alkalization on azepine to remove tartaric acid, and acting with hydrogen chloride diethyl ether to salify to prepare lorcaserin. The method has the characteristics of simple synthesis method, good reaction selectivity, high product purity, environmental protectionand low preparation cost.

Instantaneous deprotection of tosylamides and esters with Sml 2/amine/water

(Chemical Equation Presented) Sml2/amine/water mediates instantaneous cleavage of tosyl amides and tosyl esters. Highly hindered, sensitive and functionalized substrates were successfully deprotected in near quantitative yield.

A Convenient Conversion of Primary Amines into the Corresponding Halides Radical Promoted Halodeamination via N-Substituted-N-Tosylhydrazines

Treatment of 1-substituted-1-tosylhydrazines with 2 equivalents of NCS or NBS in dry THF in presence of light affords the corresponding alkyl halides in good yields.This reaction presumably involves the initial formation of a stabilized hydrazyl radical which is halogenated in a radical chain process.Elimination of p-toluenesulfinic acid and extrusion of nitrogen leads to the corresponding alkyl halide.This route provides an improved method for halodeamination under neutral reaction conditions.