14167-51-2

Basic information

• Product Name: (3a,16a)-3,16-dihydroxy-Androst-5-en-17-one
• Synonyms: (3a,16a)-3,16-dihydroxy-Androst-5-en-17-one;3a,16a-Dihydroxyandrostenone
• CAS NO: 14167-51-2
• Molecular Formula: C19H28O3
• Molecular Weight: 0
• Mol File: 14167-51-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 449.2°Cat760mmHg
• Flash Point: 239.6°C
• Appearance: /
• Density: 1.189g/cm³
• CAS DataBase Reference: (3a,16a)-3,16-dihydroxy-Androst-5-en-17-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3a,16a)-3,16-dihydroxy-Androst-5-en-17-one(14167-51-2)
• EPA Substance Registry System: (3a,16a)-3,16-dihydroxy-Androst-5-en-17-one(14167-51-2)

Safety Data

• Hazardous Substances Data: 14167-51-2(Hazardous Substances Data)

Usage

Description

(3a,16a)-3,16-dihydroxy-Androst-5-en-17-one, also known as 16a-hydroxyandrostenedione, is a steroid hormone that serves as an intermediate in the biosynthesis of estrogens and androgens in the human body. It is produced in the adrenal glands and gonads and plays a crucial role in regulating endocrine functions. (3a,16a)-3,16-dihydroxy-Androst-5-en-17-one has also demonstrated potential anti-estrogenic and anti-invasive properties, making it a promising target for cancer research. Additionally, it has been considered for use in hormonal therapies and as a precursor for the synthesis of other steroid hormones.

Uses

Used in Cancer Research:
(3a,16a)-3,16-dihydroxy-Androst-5-en-17-one is used as a target in cancer research due to its potential anti-estrogenic and anti-invasive properties. It may contribute to the development of novel therapeutic strategies for the treatment of various types of cancer.
Used in Hormonal Therapies:
In the field of hormonal therapies, (3a,16a)-3,16-dihydroxy-Androst-5-en-17-one is utilized for its role in the regulation of endocrine functions. It may help in the management of hormonal imbalances and related conditions.
Used as a Precursor in Pharmaceutical Industry:
(3a,16a)-3,16-dihydroxy-Androst-5-en-17-one is used as a precursor in the synthesis of other steroid hormones in the pharmaceutical industry. Its role in the biosynthesis of estrogens and androgens makes it a valuable component in the development of medications targeting hormonal-related health issues.

Upstream product

• 1016226-71-3 16α-bromo-5-androst-5-ene-17-one-3α-ol 
• 115350-45-3 3β-acetoxy-5α,6α-epoxy-androst-17-one, ethylene ketal 
• 13262-99-2 17,17-ethylenedioxy-androstane-3β,5α-diol 
• 15577-68-1 17,17-ethylenedioxy-3β-methanesulfonyloxy-androstane-5α-ol 
• 14456-20-3 5-androsten-3α-ol-17-one acetate 17-ethylene ketal 
• 14456-21-4 17,17-ethylenedioxy-androst-5-ene-3α-ol 
• 853-23-6 prasterone acetate 
• 2283-82-1 3α-hydroxy-androst-5-en-17-one 
• 14456-20-3 3β-acetoxy-5-androsten-17-one-17-ethyleneketal 

Relevant articles and documents

STEROID TETROL SOLID STATE FORMS-2

The invention relates to solid state forms of androst-5-ene-3α,7β,16α,17β- tetrol, formulations containing or prepared from such solid state forms and use of these materials for modulating unwanted inflammation including acute and chronic non-productive inflammation. The formulations can be used to prevent, treat or slow the progression of conditions related to autoimmunity and metabolic disorders such as arthritis, multiple sclerosis, ulcerative colitis, Type 1 diabetes and Type 2 diabetes.

DRUGS AND USES

The invention relates to methods to treat specified clinical disorders such as hyperglycemia, type 2 diabetes, arthritis and multiple sclerosis. The invention also provides methods to identify and characterize drugs, which are characterized in part by eliciting a variable biologic or therapeutic effect on a biomolecule at one time and relative normalization of the biomolecule at another time point. Compounds include 17α-ethynylandrost-5-ene-3β,7β, 17β-triol or androst-5-ene-3β,4β, 16α, 17β-tetrol, which can be used as reference standards to facilitate assessing and characterizing such candidate drugs.