1416956-15-4

Basic information

• Product Name: (S)-tert-butyl (1-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate
• Synonyms: (S)-tert-butyl (1-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate
• CAS NO: 1416956-15-4
• Molecular Weight: 663.727
• Mol File: 1416956-15-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-tert-butyl (1-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl (1-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate(1416956-15-4)
• EPA Substance Registry System: (S)-tert-butyl (1-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate(1416956-15-4)

Safety Data

• Hazardous Substances Data: 1416956-15-4(Hazardous Substances Data)

Upstream product

• 1345988-67-1 4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholinyl-1,3,5-triazin-2-yl)piperazine-1-carboxylic acid tert-butyl ester 
• 475111-38-7 4-(4-chloro-6-(2-(difluoromethyl)-1H-benzo[d]imidazole -1-yl)-1,3,5-triazin-2-yl)morpholine 
• 95-54-5 1,2-diamino-benzene 
• 705-09-9 2-(difluoromethyl)-1H-benzo[d]imidazole 

Downstream Products

• 1416956-33-6 (S)-2-amino-1-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-3-phenylpropan-1-one 

Relevant articles and documents

L-aminoacyl-triazine derivatives are isoform-selective PI3Kβ inhibitors that target nonconserved Asp862 of PI3Kβ

A series of aminoacyl-triazine derivatives based upon the pan-PI3K inhibitor ZSTK474 were identified as potent and isoform-selective inhibitors of PI3Kβ. The compounds showed selectivity based upon stereochemistry with l-amino acyl derivatives preferring PI3Kβ, while their d-congeners favored PI3Kδ. The mechanistic basis of this inhibition was studied using site-directed mutants. One Asp residue, D862, was identified as a critical participant in binding to the PI3Kβ-selective inhibitors, distinguishing this class from other reported PI3Kβ-selective inhibitors. The compounds show strong inhibition of cellular Akt phosphorylation and growth of PTEN-deficient MD-MBA-468 cells.