1417456-04-2 Usage
Description
2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride is an organic compound that serves as a key intermediate in the synthesis of idelalisib, a pharmaceutical drug. It is derived from 2-fluoro-6-nitro-benzoic acid and plays a crucial role in the HMDS/I2-catalyzed cyclocondensation and Boc deprotection process to form a nonracemic quinazoline.
Uses
Used in Pharmaceutical Industry:
2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride is used as a reactant/reagent for the synthetic preparation of idelalisib. Idelalisib is a drug that targets the PI3K-delta enzyme, which is involved in the development of certain types of cancer. The compound is essential in the HMDS/I2-catalyzed cyclocondensation and Boc deprotection of an (aminobutyrylamino)benzamide to a nonracemic quinazoline, which is a key step in the synthesis of idelalisib.
Check Digit Verification of cas no
The CAS Registry Mumber 1417456-04-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,1,7,4,5 and 6 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1417456-04:
(9*1)+(8*4)+(7*1)+(6*7)+(5*4)+(4*5)+(3*6)+(2*0)+(1*4)=152
152 % 10 = 2
So 1417456-04-2 is a valid CAS Registry Number.
1417456-04-2Relevant articles and documents
PROCESS FOR THE PREPARATION OF AMORPHOUS IDELALISIB AND ITS PREMIX
-
, (2016/10/24)
Processes for the preparation of amorphous idelalisib are provided. Processes for the preparation of a premix of amorphous idelalisib are also provided.
