141750-63-2

Basic information

• Product Name: PITAVASTATIN LACTONE
• Synonyms: PITAVASTATIN LACTONE;(4R,6S,E)-6-[2-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl]tetrahydro-4-hydroxypyran-2-one;Pitavastatin calciuM interMediates to 5, (4R, 6S, E) -6 - [2 - cyclopropyl-4 - (4 - fluorophenyl) -3 - quinoline - yl - vinyl] -4 - hydroxy -3,4,5,6 - tetrahydro-2H-pyran-2 - one;Pitavastatin Lactone DISCONTINUED;Pitavastatin calcium impurity D;(4R,6S)-6-((E)-2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one;Pitavastatin Impurity A
• CAS NO: 141750-63-2
• Molecular Formula: C25H22FNO3
• Molecular Weight: 403.45
• EINECS: 1592732-453-0
• Product Categories: All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 141750-63-2.mol
• Article Data: 0

Chemical Properties

• Melting Point: 92-95°C
• Boiling Point: 616.929 °C at 760 mmHg
• Flash Point: 326.907 °C
• Appearance: White to off-white powder
• Density: 1.373 g/cm³
• Vapor Pressure: 1.94E-19mmHg at 25°C
• Refractive Index: 1.727
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform
• PKA: 13.25±0.40(Predicted)
• CAS DataBase Reference: PITAVASTATIN LACTONE(CAS DataBase Reference)
• NIST Chemistry Reference: PITAVASTATIN LACTONE(141750-63-2)
• EPA Substance Registry System: PITAVASTATIN LACTONE(141750-63-2)

Safety Data

• Hazardous Substances Data: 141750-63-2(Hazardous Substances Data)

Usage

Description

Pitavastatin lactone is a lactone form of Pitavastatin, which is a potent HMG-CoA reductase inhibitor. It is a white to off-white powder that plays a crucial role in the regulation of cholesterol synthesis in the body. Recent studies have shown that the conversion between the acid and lactone forms of Pitavastatin occurs naturally within the body, and drug-drug interactions should be considered for both forms.

Uses

Used in Pharmaceutical Industry:
Pitavastatin lactone is used as a cholesterol-lowering agent for the treatment of hyperlipidemia and atherosclerosis. It works by inhibiting the enzyme HMG-CoA reductase, which is essential for cholesterol synthesis in the liver. This inhibition leads to a reduction in low-density lipoprotein (LDL) cholesterol levels, thereby helping to prevent the development of cardiovascular diseases.
Used in Drug Interaction Studies:
Pitavastatin lactone is used as a subject of research in drug interaction studies. Since the conversion between the acid and lactone forms occurs in the body, understanding the interactions between Pitavastatin and other drugs is essential for optimizing its therapeutic effects and minimizing potential side effects.
Used in Cardiovascular Health:
Pitavastatin lactone is used as a preventive measure for cardiovascular health. By reducing LDL cholesterol levels, it helps to decrease the risk of heart attacks, strokes, and other cardiovascular events. It is particularly beneficial for patients with a history of heart disease or those at high risk due to factors such as age, family history, or lifestyle choices.

InChI:InChI=1/C20H17ClN4O3S/c1-10-16-17(12-5-8-14(26)15(9-12)28-2)29-20(22)23-18(16)25(24-10)19(27)11-3-6-13(21)7-4-11/h3-9,17,26H,1-2H3,(H2,22,23)