1417530-85-8

Basic information

• Product Name: 3-oxo-17α-pregna-4-ene-7α-(p-methoxybenzylthia)-21,17-carbolactone
• Synonyms: 3-oxo-17α-pregna-4-ene-7α-(p-methoxybenzylthia)-21,17-carbolactone
• CAS NO: 1417530-85-8
• Molecular Weight: 494.695
• Mol File: 1417530-85-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-oxo-17α-pregna-4-ene-7α-(p-methoxybenzylthia)-21,17-carbolactone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-oxo-17α-pregna-4-ene-7α-(p-methoxybenzylthia)-21,17-carbolactone(1417530-85-8)
• EPA Substance Registry System: 3-oxo-17α-pregna-4-ene-7α-(p-methoxybenzylthia)-21,17-carbolactone(1417530-85-8)

Safety Data

• Hazardous Substances Data: 1417530-85-8(Hazardous Substances Data)

Upstream product

• 2746-25-0 p-Methoxybenzyl bromide 
• 38753-76-3 3-(3-oxo-7α-thio-17β-hydroxy-4-androsten-17α-yl)propionic acid γ-lactone 

Relevant articles and documents

A safe and practical method for the preparation of 7α-Thioether and thioester derivatives of spironolactone

Spironolactone is a renal competitive aldosterone antagonist. One of its most important metabolite is the 7α-methylthio spironolactone: thus it is very important to have an efficient and safe access to this compound, for pharmacokinetic studies. In this context, we synthesized this metabolite by thioalkylation of 7α-Thio spironolactone using Hu?nig's base with a very good yield. We also used our procedure to prepare, with an easy work-up and high yields, 7α-Thioether and thioester derivatives of spironolactone, that could be useful for further Structure-Activity Relationships studies.