14176-50-2 Usage
Description
Tiletamine Hydrochloride (200 MG) is a pharmaceutical compound that belongs to the class of anesthetic drugs. It is chemically and pharmacologically related to other anesthetics such as ketamine and phencyclidine. Tiletamine Hydrochloride is the salt form of Tiletamine and exists as odorless white crystals or a white to off-white solid. It is primarily used for closed anesthesia and general anesthesia.
Uses
Used in Veterinary Medicine:
Tiletamine Hydrochloride (200 MG) is used as an anesthetic agent for veterinary applications, particularly in the induction of anesthesia in animals. It is often combined with other drugs to provide a balanced anesthetic regimen, ensuring a smooth and controlled induction and recovery process.
Used in Human Medicine:
In human medicine, Tiletamine Hydrochloride (200 MG) is used as a component of an anesthetic cocktail, often in combination with other drugs to provide sedation, analgesia, and amnesia during medical procedures. Its use in human medicine is typically limited to specific cases due to its potential side effects and the availability of alternative anesthetic agents.
Used in Research:
Tiletamine Hydrochloride (200 MG) is also utilized in research settings to study the effects of anesthetic drugs on the central nervous system. It helps researchers understand the mechanisms of action of anesthetic agents and develop new drugs with improved safety and efficacy profiles.
Used in Drug Formulation:
As a pharmaceutical compound, Tiletamine Hydrochloride (200 MG) is used in the formulation of anesthetic drugs for various applications, including veterinary and human medicine. Its formulation allows for controlled release and targeted delivery of the drug, ensuring optimal therapeutic effects and minimizing side effects.
Indications
Tiletamine hydrochloride/zolazepam hydrochloride is used for chemical immobilization and surgical anesthesia in a wide variety of carnivores, artiodactylids, birds, reptiles, and amphibians.
Veterinary Drugs and Treatments
Telazol? is indicated for restraint or anesthesia combined with muscle relaxation in cats, and for restraint and minor procedures of short duration (≈30 minutes) which require mild to moderate analgesia in dogs. Although not officially approved, it has been used also in horses and many exotic and wild species.
Mode of action
Tiletamine hydrochloride is a dissociative anesthetic agent whose pharmacologic action is characterized by profound analgesia, normal pharyngeal-laryngeal reflexes and cataleptoid anesthesia. Used alone, tiletamine hydrochloride does not provide adequate muscle relaxation for abdominal surgical procedures. When combined with zolazepam hydrochloride, good muscle relaxation is generally attained during the phase of deep surgical anesthesia. Tilzolan is a rapid-acting anesthetic combination of tiletamine hydrochloride and zolazepam hydrochloride.
Check Digit Verification of cas no
The CAS Registry Mumber 14176-50-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,1,7 and 6 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 14176-50:
(7*1)+(6*4)+(5*1)+(4*7)+(3*6)+(2*5)+(1*0)=92
92 % 10 = 2
So 14176-50-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H17NOS.ClH/c1-2-13-12(11-7-5-9-15-11)8-4-3-6-10(12)14;/h5,7,9,13H,2-4,6,8H2,1H3;1H
14176-50-2Relevant articles and documents
Sequential [3,3]-Sigmatropic Rearrangement/Nucleophilic Arylation of N -(Benzoyloxy)enamides towards the Preparation of Cyclic β-Aryl-β-amino Alcohols
Sato, Shohei,Takeda, Norihiko,Ueda, Masafumi,Miyata, Okiko
, p. 882 - 892 (2016)
A new method has been developed for the efficient synthesis of cyclic β-aryl-β-amino alcohol derivatives bearing a tetrasubstituted carbon center via the [3,3]-sigmatropic rearrangement of N-(benzoyl oxy)enamides followed by nucleophilic arylation reactio
Synthesis of cyclopentyl 2-thienyl ketone tiletamine and tiletamine acid addition salts such as tiletamine hydrochloride
-
, (2008/06/13)
Solid, non-tin-containing catalysts can be used for the synthesis of cyclopentyl 2-thienyl ketone by the reaction of cyclopentanecarboxylic acid chloride and thiophene, while achieving new and unexpected yields. Aluminum trichloride is both cheaper than stannic chloride and it is easier to deal with as a waste stream. The successful use of graphite as a catalyst for the reaction of cyclopentanecarboxylic acid chloride and thiophene provides a mild and ecologically friendly method for carrying out the Friedel-Crafts reaction. A tiletamine-free base can be made from the cyclopentyl 2-thienyl ketone with a halide in the presence of a solvent for the cyclopentyl 2-thienyl ketone to form a halogenated cyclopentane 2-thienyl ketone; aminating the halogenated cyclopentane 2-thienyl ketone by reaction with an amine; and subjecting the reaction product to thermal rearrangement, in a suitable solvent, and at a sufficient temperature to form tiletamine free base. Each step for the formation of tiletamine free base can be accomplished using the same solvent, e.g., dichlorobenzene so that intermediates need not be isolated between reactions.
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