1417606-53-1

Basic information

• Product Name: (2S,3S,4R,E)-2,3,4-tris(benzyloxy)-7-methyl-N-((S)-2-oxoazepan-3-yl)oct-5-enamide
• CAS NO: 1417606-53-1
• Molecular Weight: 584.756
• Mol File: 1417606-53-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3S,4R,E)-2,3,4-tris(benzyloxy)-7-methyl-N-((S)-2-oxoazepan-3-yl)oct-5-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S,4R,E)-2,3,4-tris(benzyloxy)-7-methyl-N-((S)-2-oxoazepan-3-yl)oct-5-enamide(1417606-53-1)
• EPA Substance Registry System: (2S,3S,4R,E)-2,3,4-tris(benzyloxy)-7-methyl-N-((S)-2-oxoazepan-3-yl)oct-5-enamide(1417606-53-1)

Safety Data

• Hazardous Substances Data: 1417606-53-1(Hazardous Substances Data)

Upstream product

• 73111-58-7 2,3,4-Tri-O-benzyl-5,6-dideoxy-D-lyxo-hex-5-enose 

Relevant articles and documents

Concise synthesis and antitumor activity of Bengamide e and its analogs

Bengamide E (1a) and C-2 epimer (1b), free hydroxyl analogs (1c) and (1d), and shorter chain analog (1e) were synthesized by utilizing (2R,3S,4R)-2,3,4- tris(benzyloxy)hex-5-enal (2a) as the chiral building block. Preliminary biological studies revealed that only compound 1c showed slightly weaker activity than Bengamide E (1a) against MDA-MB-453 human breast carcinoma cells, MCF-7 human breast cancer cells and HCT-116 colon cancer cells, with the others being inactive. These results suggest that the correct stereochemistry at C-2, the alkylation on C-2 hydroxyl group, as well as the length of the carbon chain of Bengamide E are critical for structural recognition and binding to the target(s).