141764-83-2Relevant articles and documents
Discovery and hit-to-lead optimization of novel allosteric glucokinase activators
Lang, Martin,Seifert, Markus H.-J.,Wolf, Kristina K.,Aschenbrenner, Andrea,Baumgartner, Roland,Wieber, Tanja,Trentinaglia, Viola,Blisse, Marcus,Tajima, Nobumitsu,Yamashita, Tokuyuki,Vitt, Daniel,Noda, Hitoshi
supporting information; scheme or table, p. 5417 - 5422 (2011/10/12)
We report on a hit generation and hit-to-lead program of a novel class of glucokinase activators (GKAs). Hit compounds, activators at low glucose concentration only were identified by vHTS. Scaffold modification reliably afforded activators also at high s
Unsaturated Sulfoxides in Organic Synthesis: A New General Furan Synthesis
Chan, Wing Hong,Lee, Albert W. M.,Chan, Eddy T. T.
, p. 945 - 946 (2007/10/02)
Furans have been efficiently synthesised by a three-step reaction sequence.Michael addition of keto esters to alkenyl sulfoxides followed by Pummerer rearrangement afforded the cyclic intermediates 11 in good yield.Treatment of the latter with 3-chloroperoxybenzoic acid led by oxidation and syn-elimination of the corresponding sulfoxide, to substituted furans.