1417912-36-7Relevant articles and documents
A facile access to fluorinated pyrrolidines via catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides with methyl α- fluoroacrylate
Yan, Dingce,Li, Qinghua,Wang, Chunjiang
, p. 2714 - 2720 (2013/01/15)
Asymmetric 1,3-dipolar cycloaddition of methyl α-fluoroacrylate with azomethine ylides for the construction of optically active fluorinated pyrrolidines bearing one unique fluorinated quaternary and two tertiary stereogenic centers has been achieved with Cu(CH3CN) 4BF4/TF-BiphamPhos complexes for the first time. This catalytic system performs well over a broad scope of substrates, providing the synthetically useful adducts in good yields and excellent diastereoselectivities and good to high enantioselectivities.