1418193-25-5

Basic information

• Product Name: N-hydroxythietan-3-amine
• Synonyms: N-hydroxythietan-3-amine
• CAS NO: 1418193-25-5
• Molecular Weight: 105.161
• Mol File: 1418193-25-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-hydroxythietan-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-hydroxythietan-3-amine(1418193-25-5)
• EPA Substance Registry System: N-hydroxythietan-3-amine(1418193-25-5)

Safety Data

• Hazardous Substances Data: 1418193-25-5(Hazardous Substances Data)

Upstream product

• 3221-15-6 2-(chloromethyl)thiirane 

Relevant articles and documents

PROCESSES FOR THE PREPARATION OF THIETANAMINE

The present invention provides processes for the preparation of compounds of formula (I) including processes comprising a. reacting a compound of formula (II) with a nucleophile in the presence of water to give a compound comprising a thietane moiety in which the carbon atom at the 3 position of the thietane moiety is bonded to a nitrogen atom; wherein the nucleophile is selected the group consisting of: N3-, a sulfonamide having two hydrogen atoms bound to the nitrogen atom, a diimide having a hydrogen atom bound to the nitrogen atom or an anion thereof, NH2OH and NH3; and b. when the nucleophile used in step a. is N3- or NH2OH, reacting the compound produced in step a. with a suitable reducing agent to give a compound of formula (I); or when the nucleophile used in step a. is a sulfonamide, reacting the compound produced in step a. with a reagent suitable for cleaving the S-N bond of the sulfonamide group to give a compound of formula (I); or when the nucleophile used in step a. is a diimide, reacting the compound produced in step a. with a reagent suitable for cleaving the C-N bond of the amide group to give a compound of formula (I). The invention also relates to intermediates useful for the preparation of compounds of formula (I).