1418201-67-8

Basic information

• Product Name: 4-(4-hydroxymethyl-3-fluorophenyl)-1-methyl-1H-pyrazole
• Synonyms: 4-(4-hydroxymethyl-3-fluorophenyl)-1-methyl-1H-pyrazole
• CAS NO: 1418201-67-8
• Molecular Weight: 206.22
• Mol File: 1418201-67-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4-(4-hydroxymethyl-3-fluorophenyl)-1-methyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-hydroxymethyl-3-fluorophenyl)-1-methyl-1H-pyrazole(1418201-67-8)
• EPA Substance Registry System: 4-(4-hydroxymethyl-3-fluorophenyl)-1-methyl-1H-pyrazole(1418201-67-8)

Safety Data

• Hazardous Substances Data: 1418201-67-8(Hazardous Substances Data)

Upstream product

• 505083-04-5 3-fluoro-4-methoxycarbonylphenylboronic acid 
• 188582-62-9 4-bromo-2-fluorobenzyl alcohol 
• 761446-44-0 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 

Downstream Products

• 1392081-37-6 4-(4-(chloromethyl)-3-fluorophenyl)-1-methyl-1H-pyrazole 
• 1432436-13-9 6-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one 
• 1183623-74-6 2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzaldehyde 
• 1432436-23-1 N-(1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)-2-methylpropane-2-sulfinamide 
• 1418201-41-8 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-3-hydroxy-3-(trifluoromethyl)indolin-2-one 
• 1418201-42-9 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-3-hydroxy-3-(trifluoromethyl)indolin-2-one 
• 1418201-57-6 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-1H-benzo[d][1,3]oxazin-2(4H)-one 

Relevant articles and documents

MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention relates to compounds of formula (I), or their isotopic forms, stereoisomers, tautomers or pharmaceutically acceptable salt (s) thereof as muscarinic M1 receptor positive allosteric modulators (M1 PAMs). The present invention describes the preparation, pharmaceutical composition and the use of compound formula (I).

PYRROLOPYRIDINE OR PYRAZOLOPYRIDINE DERIVATIVES

The present invention relates to compounds of formula I wherein R1 halogen, lower alkyl, lower alkoxy, cyano, phenyl, C(O)NHCH3, C(O)NH2, lower alkyl substituted by halogen or is a five-membered heteroaryl group, optionally substituted by lower alkyl; Y1 is N or CH; Y2 is CH; and if Y1 is CH, Y1 and Y2 may form together with the C-atoms to which they are attached a ring, containing ?CH=N-N(CH3)-, -CH=N-N(H)-; X is CH or N; R is (CH2)m-cycloalkyl, optionally substituted by hydroxy, lower alkoxy or lower alkyl, or is tetrahydropyran, optionally substituted by hydroxy, or is lower alkoxy, substituted by hydroxy, or is lower alkyl substituted by one or two hydroxy, or is (CH2)m-pyridinyl, optionally substituted by hydroxy, lower alkyl or lower alkyl substituted by hydroxy, or is L-phenyl, optionally substituted by hydroxy, lower alkyl or lower alkyl substituted by hydroxy, and L is a bond, -CH(CH2OH)- or ?CH2CH(OH)-; n is 0, 1 or 2; m is 0 or 1; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. The compounds of the present invention are muscarinic M1 receptor positive allosteric modulators (PAM) and hence are useful in the treatment of diseases, mediated by the muscarinic M1 receptor, such as Alzheimer's disease, cognitive impairment, schizophrenia, pain or sleep disorders.

SUBSTITUTED 2-(4-HETEROCYCLYLBENZYL)ISOINDOLIN-1-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1

In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin- 1-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.