141821-18-3Relevant articles and documents
SYNTHESIS AND BIOLOGICAL STUDIES OF &α-ARYL-N-(2-PHENYLTHIOPHENYL)NITRONES
Sivasubramanian, S.,Ravichandran, K.,Ponnusamy, A.,Muthusubramanian S.,Mahendran, V.
, p. 165 - 170 (2007/10/02)
Fourteen new α-aryl-N-(2-phenylthiophenyl)nitrones have been synthesized.The spectral features reveal that the α-aryl and N-aryl rings are trans to each other and deviate from the plane. (2-Hydroxyphenyl)-N-(2-phenylthiophenyl)nitrone has a conformation in which the hydroxy group is closer to nitrone oxygen and other α-2-substituted phenyl-N-(2-phenylthiophenyl)nitrones prefer a conformation in which the 2-substituent of the α-aryl ring is away from the nitrone oxygen.The antimicrobial studies of these compounds reveal that while α-(2-methoxyphenyl)-N-(2-phenylthiophenyl)nitrones is moderately active against Shigella flexneri and the α-(2-hydroxyphenyl)-N-(2-phenylthiophenyl)nitrone is moderately active against Staph. aureus, Shigella flexneria and S. typhi "H".Key words: Synthesis; antimicrobial activities; α-aryl-N-(2-phenylthiophenyl)nitrones; conformation.