141887-74-3Relevant articles and documents
An azido-functionalized isocarbacyclin analogue acting as an efficient photoaffinity probe for a prostacyclin receptor
Suzuki, Masaaki,Koyano, Hiroshi,Noyori, Ryoji,Hashimoto, Hitoshi,Negishi, Manabu,Ichikawa, Atsushi,Ito, Seiji
, p. 2635 - 2658 (2007/10/02)
A stable prostacyclin analogue, (15S)-18c, having an azidophenyl group as a photoaffinity labeling functionality has been synthesized. This compound has a sufficiently high affinity to the prostacyclin receptor protein in mastocytoma P-815 cells, exhibiting an IC50 value of 3 nM for the replacement of iloprost bound to the receptor protein. A photoaffinity probe compound, [3H]-(15S)-18c, is obtainable by reduction of the ketone 16c with [3H]NaBH4 - CeCl3 followed by alkaline hydrolysis of the methyl ester.