1419063-02-7

Basic information

• Product Name: tert-butyl 4-(5-(3-(1-(2-cyano-1,2-dimethylhydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamoyl)phenyl)pyridin-2-yl)piperazine-1-carboxylate
• CAS NO: 1419063-02-7
• Molecular Weight: 563.7
• Mol File: 1419063-02-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(5-(3-(1-(2-cyano-1,2-dimethylhydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamoyl)phenyl)pyridin-2-yl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(5-(3-(1-(2-cyano-1,2-dimethylhydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamoyl)phenyl)pyridin-2-yl)piperazine-1-carboxylate(1419063-02-7)
• EPA Substance Registry System: tert-butyl 4-(5-(3-(1-(2-cyano-1,2-dimethylhydrazinyl)-4-methyl-1-oxopentan-2-ylcarbamoyl)phenyl)pyridin-2-yl)piperazine-1-carboxylate(1419063-02-7)

Safety Data

• Hazardous Substances Data: 1419063-02-7(Hazardous Substances Data)

Upstream product

• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 496786-98-2 2-(4-tert-butyloxycarbonyl-piperizin-1-yl)pyridine-5-boronic acid pinacol ester 
• 1403588-00-0 3-bromo-N-(1-(2-cyano-1,2-dimethylhydrazinyl)-4-methyl-1-oxopentan-2-yl)benzamide 
• 496019-63-7 2-(3-bromobenzamido)-4-methylpentanoic acid 
• 1037560-77-2 methyl 2-(3-bromobenzamido)-4-methylpentanoate 
• 61-90-5 L-leucine 
• 1711-09-7 3-bromobenzoyl chloride 
• 585-76-2 m-bromobenzoic acid 

Relevant articles and documents

Highly selective azadipeptide nitrile inhibitors for cathepsin K: Design, synthesis and activity assays

We have developed a series of azadipeptide nitriles with different P3 groups. A triaryl meta-phenyl derivative, compound 13, was not only a potent inhibitor for cathepsin K (Ki = 0.0031 nM), but also highly selective over both cathepsins B and S (～1000-fold). A protein-ligand docking study performed on the series provided a possible explanation why compound 13 could be significantly more potent than the others, especially compound 12 in the same series.