1419165-36-8Relevant articles and documents
Naphthalene-based environmentally sensitive fluorescent 8-substituted 2′-deoxyadenosines: Application to DNA detection
Suzuki, Azusa,Takahashi, Naoya,Okada, Yuji,Saito, Isao,Nemoto, Nobukatsu,Saito, Yoshio
, p. 886 - 892 (2013/02/23)
We synthesized various C8-naphthylethynylated 2′-deoxyadenosine derivatives and investigated their photophysical properties. Among them, cyano- and N,N-dimethylamino-substituted 8-naphthylethynylated 2′-deoxyadenosine derivatives (cnA and dnA) showed strong fluorescence with high quantum yields and a remarkable solvatofuorochromicity. In particular, fluorescence of N,N-dimethylamino-substituted 2, 6dnA was not quenched by neighboring guanines (Gs) when incorporated in DNA duplexes, in contrast to cnA. We developed a new fluorescent probe containing 2,6dnA that can be used for the detection of target DNA via a bulge formation regardless of the neighboring sequences.