141982-21-0

Basic information

• Product Name: 2-Hydroxy-2-methyl-2H-naphthalene-1-one
• Synonyms: 2-Hydroxy-2-methyl-2H-naphthalene-1-one
• CAS NO: 141982-21-0
• Molecular Weight: 174.199
• Mol File: 141982-21-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Hydroxy-2-methyl-2H-naphthalene-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-2-methyl-2H-naphthalene-1-one(141982-21-0)
• EPA Substance Registry System: 2-Hydroxy-2-methyl-2H-naphthalene-1-one(141982-21-0)

Safety Data

• Hazardous Substances Data: 141982-21-0(Hazardous Substances Data)

Upstream product

• 7469-77-4 2-methylnaphthalen-1-ol 

Relevant articles and documents

Asymmetric hydroxylative phenol dearomatization promoted by chiral binaphthylic and biphenylic iodanes

The long-standing quest for chiral hypervalent organoiodine compounds (i.e., iodanes) as metal-free reagents for asymmetric synthesis continues. Although remarkable progress has recently been made in organoiodine-catalyzed reactions using a terminal oxidant in stoichiometric amounts, there is still a significant need for "flaskable" chiral iodane reagents. Herein, we describe the synthesis of new iodobinaphthyls and iodobiphenyls, their successful and selective DMDO-mediated oxidation into either λ3- or λ5-iodanes, and the evaluation of their capacity to promote asymmetric hydroxylative phenol dearomatization (HPD) reactions. Most notably, a C2-symmetrical biphenylic λ5-iodane promoted the HPD-induced conversion of the monoterpene thymol into the corresponding ortho-quinol-based [4+2] cyclodimer (i.e., bis(thymol)) with enantiomeric excesses of up to 94 %.